1pvv

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{{STRUCTURE_1pvv| PDB=1pvv | SCENE= }}
{{STRUCTURE_1pvv| PDB=1pvv | SCENE= }}
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'''Refined Structure of Pyrococcus furiosus Ornithine Carbamoyltransferase at 1.87 A'''
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===Refined Structure of Pyrococcus furiosus Ornithine Carbamoyltransferase at 1.87 A===
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==Overview==
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Using synchrotron radiation, X-ray data have been collected from Pyrococcus furiosus ornithine carbamoyltransferase (Pfu OTCase) to a maximal resolution of 1.87 A, allowing the refinement of a previous structure at 2.7 A [Villeret et al. (1998), Proc. Natl Acad. Sci. USA, 95, 2801-2806]. Thanks to the high resolution of this refined structure, two sulfate ions and 191 water molecules could be localized directly from the electron-density maps. The identification of these molecules allowed a more rigorous description of the active site and the identification of residues involved in binding carbamoyl phosphate. The improved quality of the model resulted in a better definition of several loops and the various interfaces. The dodecameric protein is composed of four catalytic trimers disposed in a tetrahedral manner. The extreme thermal stability of Pfu OTCase is mainly the result of the strengthening of the intersubunit interactions in a trimer and oligomerization of the trimers into a dodecamer. Interfaces between monomers in a catalytic trimer are characterized by an increase in ion-pair networks compared with mesophilic OTCases. However, the interfaces between catalytic trimers in the dodecameric oligomer are mainly hydrophobic and also involve aromatic-aromatic and cation-pi interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 14646072 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14646072}}
==About this Structure==
==About this Structure==
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[[Category: Wouters, J.]]
[[Category: Wouters, J.]]
[[Category: Dodecamer]]
[[Category: Dodecamer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:32:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:02:51 2008''

Revision as of 21:02, 28 July 2008

Image:1pvv.png

Template:STRUCTURE 1pvv

Refined Structure of Pyrococcus furiosus Ornithine Carbamoyltransferase at 1.87 A

Template:ABSTRACT PUBMED 14646072

About this Structure

1PVV is a Single protein structure of sequence from Pyrococcus furiosus. Full crystallographic information is available from OCA.

Reference

Refined structure of Pyrococcus furiosus ornithine carbamoyltransferase at 1.87 A., Massant J, Wouters J, Glansdorff N, Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2140-9. Epub 2003, Nov 27. PMID:14646072

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