1pwy

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{{STRUCTURE_1pwy| PDB=1pwy | SCENE= }}
{{STRUCTURE_1pwy| PDB=1pwy | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN PNP COMPLEXED WITH ACYCLOVIR'''
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===CRYSTAL STRUCTURE OF HUMAN PNP COMPLEXED WITH ACYCLOVIR===
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==Overview==
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In human, purine nucleoside phosphorylase (HsPNP) is responsible for degradation of deoxyguanosine and genetic deficiency of this enzyme leads to profound T-cell mediated immunosuppression. PNP is therefore a target for inhibitor development aiming at T-cell immune response modulation and has been submitted to extensive structure-based drug design. This work reports the first crystallographic study of human PNP complexed with acyclovir (HsPNP:Acy). Acyclovir is a potent clinically useful inhibitor of replicant herpes simplex virus that also inhibits human PNP but with a relatively lower inhibitory activity (K(i)=90 microM). Analysis of the structural differences among the HsPNP:Acy complex, PNP apoenzyme, and HsPNP:Immucillin-H provides explanation for inhibitor binding, refines the purine-binding site, and can be used for future inhibitor design.
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(as it appears on PubMed at http://www.pubmed.gov), where 12914786 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12914786}}
==About this Structure==
==About this Structure==
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[[Category: Purine nucleoside phosphorylase]]
[[Category: Purine nucleoside phosphorylase]]
[[Category: Synchrotron]]
[[Category: Synchrotron]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:40:22 2008''

Revision as of 18:40, 28 July 2008

Image:1pwy.png

Template:STRUCTURE 1pwy

CRYSTAL STRUCTURE OF HUMAN PNP COMPLEXED WITH ACYCLOVIR

Template:ABSTRACT PUBMED 12914786

About this Structure

1PWY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human purine nucleoside phosphorylase complexed with acyclovir., dos Santos DM, Canduri F, Pereira JH, Vinicius Bertacine Dias M, Silva RG, Mendes MA, Palma MS, Basso LA, de Azevedo WF Jr, Santos DS, Biochem Biophys Res Commun. 2003 Aug 29;308(3):553-9. PMID:12914786

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