7qxy
From Proteopedia
(Difference between revisions)
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<StructureSection load='7qxy' size='340' side='right'caption='[[7qxy]], [[Resolution|resolution]] 1.48Å' scene=''> | <StructureSection load='7qxy' size='340' side='right'caption='[[7qxy]], [[Resolution|resolution]] 1.48Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QXY FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.478Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.478Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=I1G:3-[4-[5-[4-[[4-(acetamidomethyl)piperidin-1-ium-1-yl]methyl]-6-[3,5-bis(chloranyl)phenyl]pyridin-2-yl]oxypyrimidin-2-yl]piperazin-1-ium-1-yl]propanoate'>I1G</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=I1G:3-[4-[5-[4-[[4-(acetamidomethyl)piperidin-1-ium-1-yl]methyl]-6-[3,5-bis(chloranyl)phenyl]pyridin-2-yl]oxypyrimidin-2-yl]piperazin-1-ium-1-yl]propanoate'>I1G</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qxy OCA], [https://pdbe.org/7qxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qxy RCSB], [https://www.ebi.ac.uk/pdbsum/7qxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qxy ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qxy OCA], [https://pdbe.org/7qxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qxy RCSB], [https://www.ebi.ac.uk/pdbsum/7qxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qxy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/FURIN_HUMAN FURIN_HUMAN] Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.<ref>PMID:7690548</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Brandstetter H]] | [[Category: Brandstetter H]] | ||
[[Category: Dahms SO]] | [[Category: Dahms SO]] | ||
[[Category: Pautsch A]] | [[Category: Pautsch A]] | ||
Current revision
X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 3
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