1pxy

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{{STRUCTURE_1pxy| PDB=1pxy | SCENE= }}
{{STRUCTURE_1pxy| PDB=1pxy | SCENE= }}
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'''Crystal structure of the actin-crosslinking core of Arabidopsis fimbrin'''
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===Crystal structure of the actin-crosslinking core of Arabidopsis fimbrin===
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==Overview==
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Filamentous actin is organized into bundles and orthogonal networks by the fimbrin/alpha-actinin superfamily of F-actin crosslinking proteins. The crystal structure of the Arabidopsis thaliana and Schizosaccharomyces pombe fimbrin cores provides the first description of a functional F-actin crosslinking protein and highlights the compact and distinctly asymmetric organization of the fimbrin molecule, in which the two actin binding domains present distinct surfaces to solvent. The mapping of functionally important residues onto the structure affords new insights into the binding process and provides additional constraints which must be accommodated by models for F-actin binding and crosslinking. Most strikingly, this work provides unique insight into the mechanistic features of conditional-lethal mutants and their extragenic suppressors, which highlight conformational and dynamic properties required for fimbrin function. These results underscore the power of jointly considering structural and genetic suppressor data for obtaining unexpected and biologically relevant mechanistic information.
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(as it appears on PubMed at http://www.pubmed.gov), where 15274920 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15274920}}
==About this Structure==
==About this Structure==
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[[Category: Psi]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:37:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:05:23 2008''

Revision as of 03:05, 28 July 2008

Image:1pxy.png

Template:STRUCTURE 1pxy

Crystal structure of the actin-crosslinking core of Arabidopsis fimbrin

Template:ABSTRACT PUBMED 15274920

About this Structure

1PXY is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

Structure of the actin crosslinking core of fimbrin., Klein MG, Shi W, Ramagopal U, Tseng Y, Wirtz D, Kovar DR, Staiger CJ, Almo SC, Structure. 2004 Jun;12(6):999-1013. PMID:15274920

Page seeded by OCA on Mon Jul 28 06:05:23 2008

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