1pzd

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{{STRUCTURE_1pzd| PDB=1pzd | SCENE= }}
{{STRUCTURE_1pzd| PDB=1pzd | SCENE= }}
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'''Structural Identification of a conserved appendage domain in the carboxyl-terminus of the COPI gamma-subunit.'''
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===Structural Identification of a conserved appendage domain in the carboxyl-terminus of the COPI gamma-subunit.===
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==Overview==
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The formation of coated vesicles is a fundamental step in many intracellular trafficking pathways. COPI and clathrin represent two important and distinct sets of vesicle coating machinery, involved primarily in mediating intra-Golgi and endocytic transport, respectively. Here we identify an important functional region at the carboxyl terminus of the gamma subunit of the COPI complex (gammaCOP) and describe the X-ray crystal structure of this domain at 2.3 A resolution. This domain of gammaCOP exhibits unexpected structural similarity to the carboxyl-terminal appendage domains of the alpha and beta subunits of the AP2 adaptor proteins, integral components of clathrin-coated vesicles. The remarkable structural conservation exhibited by the gammaCOP appendage domain, coupled with functional data and primary sequence analysis, supports a model of COPI function with significant structural and mechanistic parallels to vesicular transport by the clathrin/AP2 system.
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(as it appears on PubMed at http://www.pubmed.gov), where 14527408 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14527408}}
==About this Structure==
==About this Structure==
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[[Category: Ear domain]]
[[Category: Ear domain]]
[[Category: Platform domain]]
[[Category: Platform domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:40:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:54:55 2008''

Revision as of 10:54, 28 July 2008

Image:1pzd.png

Template:STRUCTURE 1pzd

Structural Identification of a conserved appendage domain in the carboxyl-terminus of the COPI gamma-subunit.

Template:ABSTRACT PUBMED 14527408

About this Structure

1PZD is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Conserved structural motifs in intracellular trafficking pathways: structure of the gammaCOP appendage domain., Hoffman GR, Rahl PB, Collins RN, Cerione RA, Mol Cell. 2003 Sep;12(3):615-25. PMID:14527408

Page seeded by OCA on Mon Jul 28 13:54:55 2008

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