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1q0b

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{{STRUCTURE_1q0b| PDB=1q0b | SCENE= }}
{{STRUCTURE_1q0b| PDB=1q0b | SCENE= }}
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'''Crystal structure of the motor protein KSP in complex with ADP and monastrol'''
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===Crystal structure of the motor protein KSP in complex with ADP and monastrol===
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==Overview==
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We report here the first inhibitor-bound structure of a mitotic motor protein. The 1.9 A resolution structure of the motor domain of KSP, bound with the small molecule monastrol and Mg2+ x ADP, reveals that monastrol confers inhibition by "induced-fitting" onto the protein some 12 A away from the catalytic center of the enzyme, resulting in the creation of a previously non-existing binding pocket. The structure provides new insights into the biochemical and mechanical mechanisms of the mitotic motor domain. Inhibition of KSP provides a novel mechanism to arrest mitotic spindle formation, a target of several approved and investigative anti-cancer agents. The structural information gleaned from this novel pocket offers a new angle for the design of anti-mitotic agents.
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(as it appears on PubMed at http://www.pubmed.gov), where 14672662 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14672662}}
==About this Structure==
==About this Structure==
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[[Category: Monastrol]]
[[Category: Monastrol]]
[[Category: Motor protein]]
[[Category: Motor protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:50:16 2008''

Revision as of 12:50, 27 July 2008

Image:1q0b.png

Template:STRUCTURE 1q0b

Crystal structure of the motor protein KSP in complex with ADP and monastrol

Template:ABSTRACT PUBMED 14672662

About this Structure

1Q0B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Inhibition of a mitotic motor protein: where, how, and conformational consequences., Yan Y, Sardana V, Xu B, Homnick C, Halczenko W, Buser CA, Schaber M, Hartman GD, Huber HE, Kuo LC, J Mol Biol. 2004 Jan 9;335(2):547-54. PMID:14672662

Page seeded by OCA on Sun Jul 27 15:50:16 2008

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