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1q0d

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[[Image:1q0d.gif|left|200px]]
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==Overview==
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{{ABSTRACT_15173586}}
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Superoxide dismutases (SODs, EC 1.15.1.1) are ubiquitous enzymes that efficiently catalyze the dismutation of superoxide radical anions to protect biological molecules from oxidative damage. The crystal structure of nickel-containing SOD (NiSOD) from Streptomyces seoulensis was determined for the resting, x-ray-reduced, and thiosulfate-reduced enzyme state. NiSOD is a homohexamer consisting of four-helix-bundle subunits. The catalytic center resides in the N-terminal active-site loop, where a Ni(III) ion is coordinated by the amino group of His-1, the amide group of Cys-2, two thiolate groups of Cys-2 and Cys-6, and the imidazolate of His-1 as axial ligand that is lost in the chemically reduced state as well as after x-ray-induced reduction. This structure represents a third class of SODs concerning the catalytic metal species, subunit structure, and oligomeric organization. It adds a member to the small number of Ni-metalloenzymes and contributes with its Ni(III) active site to the general understanding of Ni-related biochemistry. NiSOD is shown to occur also in bacteria other than Streptomyces and is predicted to be present in some cyanobacteria.
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==About this Structure==
==About this Structure==
1Q0D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_seoulensis Streptomyces seoulensis]. The following page contains interesting information on the relation of 1Q0D with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb94_1.html Superoxide Dismutase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q0D OCA].
1Q0D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_seoulensis Streptomyces seoulensis]. The following page contains interesting information on the relation of 1Q0D with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb94_1.html Superoxide Dismutase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q0D OCA].
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==Reference==
 
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Crystal structure of nickel-containing superoxide dismutase reveals another type of active site., Wuerges J, Lee JW, Yim YI, Yim HS, Kang SO, Djinovic Carugo K, Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8569-74. Epub 2004 Jun 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15173586 15173586]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Streptomyces seoulensis]]
[[Category: Streptomyces seoulensis]]
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[[Category: Yim, Y I.]]
[[Category: Yim, Y I.]]
[[Category: Homohexamer of four-helix bundle]]
[[Category: Homohexamer of four-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:42:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:50:51 2008''

Revision as of 14:50, 26 June 2008

Image:1q0d.png

Template:STRUCTURE 1q0d

Crystal structure of Ni-containing superoxide dismutase with Ni-ligation corresponding to the oxidized state


Template:ABSTRACT 15173586

About this Structure

1Q0D is a Single protein structure of sequence from Streptomyces seoulensis. The following page contains interesting information on the relation of 1Q0D with [Superoxide Dismutase]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:50:51 2008

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