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1q0e

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[[Image:1q0e.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1q0e| PDB=1q0e | SCENE= }}
{{STRUCTURE_1q0e| PDB=1q0e | SCENE= }}
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'''Atomic resolution (1.15 ) crystal structure of bovine copper, zinc superoxide dismutase'''
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===Atomic resolution (1.15 ) crystal structure of bovine copper, zinc superoxide dismutase===
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==Overview==
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Copper zinc superoxide dismutase (CuZnSOD) forms a crucial component of the cellular response to oxidative stress by catalyzing the dismutation of the superoxide radical to hydrogen peroxide and water. Mutations in human CuZnSOD are associated with the development of familial amyotrophic lateral sclerosis (motor neuron disease). We have determined the structure of fully reduced bovine CuZnSOD to 1.15 A, the only atomic resolution structure for an intact CuZnSOD and one of only a small number for metalloproteins. For the first time, both subunits have been captured with the three coordinate Cu(I) ligation required by the generally accepted catalytic mechanism, where dismutation of the superoxide radical occurs via reduction of Cu. Furthermore, the improved resolution compared to previous studies (to 1.65 A) has allowed a more detailed examination of the metal center environment and its associated water network in the active site channel, facilitating the analysis of potential proton transfer routes.
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The line below this paragraph, {{ABSTRACT_PUBMED_12906825}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12906825 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12906825}}
==About this Structure==
==About this Structure==
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[[Category: Superoxide dismutase]]
[[Category: Superoxide dismutase]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:42:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:44:52 2008''

Revision as of 23:44, 28 July 2008

Image:1q0e.png

Template:STRUCTURE 1q0e

Atomic resolution (1.15 ) crystal structure of bovine copper, zinc superoxide dismutase

Template:ABSTRACT PUBMED 12906825

About this Structure

1Q0E is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure of fully reduced bovine copper zinc superoxide dismutase at 1.15 A., Hough MA, Hasnain SS, Structure. 2003 Aug;11(8):937-46. PMID:12906825

Page seeded by OCA on Tue Jul 29 02:44:52 2008

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