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1q0v

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{{STRUCTURE_1q0v| PDB=1q0v | SCENE= }}
{{STRUCTURE_1q0v| PDB=1q0v | SCENE= }}
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'''Solution Structure of Tandem UIMs of Vps27'''
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===Solution Structure of Tandem UIMs of Vps27===
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==Overview==
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Monoubiquitylation is a well-characterized signal for the internalization and sorting of integral membrane proteins to distinct cellular organelles. Recognition and transmission of monoubiquitin signals is mediated by a variety of ubiquitin-binding motifs such as UIM, UBA, UEV, VHS and CUE in endocytic proteins. The yeast Vps27 protein requires two UIMs for efficient interactions with ubiquitin and for sorting cargo into multivesicular bodies. Here we show that the individual UIMs of Vps27 exist as autonomously folded alpha-helices that bind ubiquitin independently, non-cooperatively and with modest affinity. The Vps27 N-terminal UIM engages the Leu8-Ile44-Val70 hydrophobic patch of ubiquitin through a helical surface conserved in UIMs of diverse proteins, including that of the S5a proteasomal regulatory subunit. The Leu8-Ile44-Val70 ubiquitin surface is also the site of interaction for CUE and UBA domains in endocytic proteins, consistent with the view that ubiquitin-binding endocytic proteins act serially on the same monoubiquitylated cargo during transport from cell surface to the lysosome.
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(as it appears on PubMed at http://www.pubmed.gov), where 12970172 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12970172}}
==About this Structure==
==About this Structure==
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1Q0V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q0V OCA].
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1Q0V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q0V OCA].
==Reference==
==Reference==
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[[Category: Non-interacting alpha-helice]]
[[Category: Non-interacting alpha-helice]]
[[Category: Stable]]
[[Category: Stable]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:43:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:18:43 2008''

Revision as of 11:18, 27 July 2008

Image:1q0v.png

Template:STRUCTURE 1q0v

Solution Structure of Tandem UIMs of Vps27

Template:ABSTRACT PUBMED 12970172

About this Structure

1Q0V is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Solution structure of Vps27 UIM-ubiquitin complex important for endosomal sorting and receptor downregulation., Swanson KA, Kang RS, Stamenova SD, Hicke L, Radhakrishnan I, EMBO J. 2003 Sep 15;22(18):4597-606. PMID:12970172

Page seeded by OCA on Sun Jul 27 14:18:43 2008

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