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1q1q

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{{STRUCTURE_1q1q| PDB=1q1q | SCENE= }}
{{STRUCTURE_1q1q| PDB=1q1q | SCENE= }}
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'''Crystal structure of human pregnenolone sulfotransferase (SULT2B1a) in the presence of PAP'''
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===Crystal structure of human pregnenolone sulfotransferase (SULT2B1a) in the presence of PAP===
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==Overview==
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The gene for human hydroxysteroid sulfotransferase (SULT2B1) encodes two peptides, SULT2B1a and SULT2B1b, that differ only at their amino termini. SULT2B1b has a predilection for cholesterol but is also capable of sulfonating pregnenolone, whereas SULT2B1a preferentially sulfonates pregnenolone and only minimally sulfonates cholesterol. We have determined the crystal structure of SULT2B1a and SULT2B1b bound to the substrate donor product 3'-phosphoadenosine 5'-phosphate at 2.9 and 2.4 A, respectively, as well as SULT2B1b in the presence of the acceptor substrate pregnenolone at 2.3 A. These structures reveal a different catalytic binding orientation for the substrate from a previously determined structure of hydroxysteroid sulfotransferase (SULT2A1) binding dehydroepiandrosterone. In addition, the amino-terminal helix comprising residues Asp19 to Lys26, which determines the specificity difference between the SULT2B1 isoforms, becomes ordered upon pregnenolone binding, covering the substrate binding pocket.
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(as it appears on PubMed at http://www.pubmed.gov), where 12923182 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12923182}}
==About this Structure==
==About this Structure==
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[[Category: Sulfotransferase]]
[[Category: Sulfotransferase]]
[[Category: Sult2b1]]
[[Category: Sult2b1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:45:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:32:21 2008''

Revision as of 15:32, 27 July 2008

Image:1q1q.png

Template:STRUCTURE 1q1q

Crystal structure of human pregnenolone sulfotransferase (SULT2B1a) in the presence of PAP

Template:ABSTRACT PUBMED 12923182

About this Structure

1Q1Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms., Lee KA, Fuda H, Lee YC, Negishi M, Strott CA, Pedersen LC, J Biol Chem. 2003 Nov 7;278(45):44593-9. Epub 2003 Aug 14. PMID:12923182

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