1q1v

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[[Image:1q1v.gif|left|200px]]
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{{Seed}}
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[[Image:1q1v.png|left|200px]]
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{{STRUCTURE_1q1v| PDB=1q1v | SCENE= }}
{{STRUCTURE_1q1v| PDB=1q1v | SCENE= }}
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'''Structure of the Oncoprotein DEK: a putative DNA-binding Domain Related to the Winged Helix Motif'''
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===Structure of the Oncoprotein DEK: a putative DNA-binding Domain Related to the Winged Helix Motif===
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==Overview==
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The chromatin-associated protein DEK was first identified as a fusion protein in patients with a subtype of acute myelogenous leukemia. It has since become associated with diverse human ailments ranging from cancers to autoimmune diseases. Despite much research effort, the biochemical basis for these clinical connections has yet to be explained. We have identified a structural domain in the C-terminal region of DEK [DEK(309-375)]. DEK(309-375) implies clinical importance because it can reverse the characteristic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients. We determined the solution structure of DEK(309-375) by nuclear magnetic resonance spectroscopy, and found it to be structurally homologous to the E2F/DP transcription factor family. On the basis of this homology, we tested whether DEK(309-375) could bind DNA and identified the DNA-interacting surface. DEK presents a hydrophobic surface on the side opposite the DNA-interacting surface. The structure of the C-terminal region of DEK provides insights into the protein function of DEK.
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The line below this paragraph, {{ABSTRACT_PUBMED_15238633}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15238633 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15238633}}
==About this Structure==
==About this Structure==
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1Q1V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1V OCA].
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1Q1V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1V OCA].
==Reference==
==Reference==
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[[Category: Matsuo, H.]]
[[Category: Matsuo, H.]]
[[Category: Winged-helix motif]]
[[Category: Winged-helix motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:45:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:02:55 2008''

Revision as of 10:03, 27 July 2008

Image:1q1v.png

Template:STRUCTURE 1q1v

Structure of the Oncoprotein DEK: a putative DNA-binding Domain Related to the Winged Helix Motif

Template:ABSTRACT PUBMED 15238633

About this Structure

1Q1V is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution NMR structure of the C-terminal domain of the human protein DEK., Devany M, Kotharu NP, Matsuo H, Protein Sci. 2004 Aug;13(8):2252-9. Epub 2004 Jul 6. PMID:15238633

Page seeded by OCA on Sun Jul 27 13:02:55 2008

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