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1q25

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[[Image:1q25.gif|left|200px]]
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{{STRUCTURE_1q25| PDB=1q25 | SCENE= }}
{{STRUCTURE_1q25| PDB=1q25 | SCENE= }}
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'''Crystal structure of N-terminal 3 domains of CI-MPR'''
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===Crystal structure of N-terminal 3 domains of CI-MPR===
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==Overview==
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The 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR) mediates the intracellular transport of newly synthesized lysosomal enzymes containing mannose 6-phosphate on their N-linked oligosaccharides. In addition to its role in lysosome biogenesis, the CI-MPR interacts with a number of different extracellular ligands at the cell surface, including latent transforming growth factor-beta, insulin-like growth factor-II, plasminogen, and urokinase-type plasminogen activator receptor (uPAR), to regulate cell growth and motility. We have solved the crystal structure of the N-terminal 432 residues of the CI-MPR at 1.8 A resolution, which encompass three out of the 15 repetitive domains of its extracytoplasmic region. The three domains, which exhibit similar topology to each other and to the 46 kDa cation-dependent mannose 6-phosphate receptor, assemble into a compact structure with the uPAR/plasminogen and the carbohydrate-binding sites situated on opposite faces of the molecule. Knowledge of the arrangement of these three domains has allowed us to propose a model of the entire extracytoplasmic region of the CI-MPR that provides a context with which to envision the numerous binding interactions carried out by this multi-faceted receptor.
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The line below this paragraph, {{ABSTRACT_PUBMED_15085180}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15085180 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15085180}}
==About this Structure==
==About this Structure==
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[[Category: P-lectin]]
[[Category: P-lectin]]
[[Category: Receptor]]
[[Category: Receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:46:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:29:41 2008''

Revision as of 21:29, 27 July 2008

Image:1q25.png

Template:STRUCTURE 1q25

Crystal structure of N-terminal 3 domains of CI-MPR

Template:ABSTRACT PUBMED 15085180

About this Structure

1Q25 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure of uPAR, plasminogen, and sugar-binding sites of the 300 kDa mannose 6-phosphate receptor., Olson LJ, Yammani RD, Dahms NM, Kim JJ, EMBO J. 2004 May 19;23(10):2019-28. Epub 2004 Apr 15. PMID:15085180

Page seeded by OCA on Mon Jul 28 00:29:41 2008

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