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1q2k

From Proteopedia

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[[Image:1q2k.jpg|left|200px]]
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{{Seed}}
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[[Image:1q2k.png|left|200px]]
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{{STRUCTURE_1q2k| PDB=1q2k | SCENE= }}
{{STRUCTURE_1q2k| PDB=1q2k | SCENE= }}
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'''Solution structure of BmBKTx1 a new potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch'''
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===Solution structure of BmBKTx1 a new potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch===
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==Overview==
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BmBKTx1 is a 31-amino acid peptide identified from the venom of the Chinese scorpion Buthus martensi Karsch, blocking high-conductance calcium-activated potassium channels. Sequence homology analysis indicates that BmBKTx1 is a new subfamily of short-chain alpha-KTx toxins of the potassium channel, which we term alpha-KTx19. Synthetic BmBKTx1 was prepared by using solid-phase peptide synthesis. Two-dimensional NMR spectroscopy techniques were used to determine the solution structure of BmBKTx1. The results show that the BmBKTx1 forms a typical cysteine-stabilized alpha/beta scaffold adopted by most short-chain scorpion toxins. The structure of BmBKTx1 consists of a two-stranded antiparallel beta-sheet (residues 20-29) and an alpha-helix (residues 5-15). The three-dimensional structure of BmBKTx1 was also compared with those of two function-related scorpion toxins, charybdotoxin (ChTx) and BmTx1, and their structural and functional implications are discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_15049683}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15049683 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15049683}}
==About this Structure==
==About this Structure==
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1Q2K is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q2K OCA].
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1Q2K is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q2K OCA].
==Reference==
==Reference==
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[[Category: Alpha-helix]]
[[Category: Alpha-helix]]
[[Category: Beta-sheet]]
[[Category: Beta-sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:47:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:05:48 2008''

Revision as of 09:05, 29 July 2008

Image:1q2k.png

Template:STRUCTURE 1q2k

Solution structure of BmBKTx1 a new potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch

Template:ABSTRACT PUBMED 15049683

About this Structure

1Q2K is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure of BmBKTx1, a new BKCa1 channel blocker from the Chinese scorpion Buthus martensi Karsch., Cai Z, Xu C, Xu Y, Lu W, Chi CW, Shi Y, Wu J, Biochemistry. 2004 Apr 6;43(13):3764-71. PMID:15049683

Page seeded by OCA on Tue Jul 29 12:05:48 2008

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