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1q2u

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[[Image:1q2u.gif|left|200px]]
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{{STRUCTURE_1q2u| PDB=1q2u | SCENE= }}
{{STRUCTURE_1q2u| PDB=1q2u | SCENE= }}
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'''Crystal structure of DJ-1/RS and implication on familial Parkinson's disease'''
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===Crystal structure of DJ-1/RS and implication on familial Parkinson's disease===
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==Overview==
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DJ-1 is a protein involved in multiple physiological processes, including cancer, Parkinson's disease, and male fertility. It is unknown how DJ-1 functions in the apparently different systems. The crystal structure of DJ-1 at 1.6 A resolution shows that DJ-1 is a helix-strand-helix sandwich and forms a dimer. The DJ-1 structure is similar to the members of the intracellular protease PfpI family. However, the catalytic triad of Cys-His-Glu is not strictly conserved in DJ-1, implying that DJ-1 has a different catalytic mechanism if it acts as a protease or DJ-1 serves as a regulatory protein in the physiological processes. The structure shows that Leu166 positions in the middle of a helix and thus predicts that the L166P mutation will bend the helix and impact the dimerization of DJ-1. As a result, the conformational changes may diminish the DJ-1 binding with its partner, leading to the familial Parkinson's disease caused by the single L166P mutation.
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(as it appears on PubMed at http://www.pubmed.gov), where 12914946 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12914946}}
==About this Structure==
==About this Structure==
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[[Category: Parkinson's disease]]
[[Category: Parkinson's disease]]
[[Category: Protein inhibitor of activated stat]]
[[Category: Protein inhibitor of activated stat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:47:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:17:41 2008''

Revision as of 23:17, 27 July 2008

Image:1q2u.png

Template:STRUCTURE 1q2u

Crystal structure of DJ-1/RS and implication on familial Parkinson's disease

Template:ABSTRACT PUBMED 12914946

About this Structure

1Q2U is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of DJ-1/RS and implication on familial Parkinson's disease., Huai Q, Sun Y, Wang H, Chin LS, Li L, Robinson H, Ke H, FEBS Lett. 2003 Aug 14;549(1-3):171-5. PMID:12914946

Page seeded by OCA on Mon Jul 28 02:17:41 2008

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