1q3f

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[[Image:1q3f.gif|left|200px]]
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{{STRUCTURE_1q3f| PDB=1q3f | SCENE= }}
{{STRUCTURE_1q3f| PDB=1q3f | SCENE= }}
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'''Uracil DNA glycosylase bound to a cationic 1-aza-2'-deoxyribose-contianing DNA'''
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===Uracil DNA glycosylase bound to a cationic 1-aza-2'-deoxyribose-contianing DNA===
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==Overview==
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The DNA repair enzyme uracil DNA glycosylase has been crystallized with a cationic 1-aza-2'-deoxyribose-containing DNA that mimics the ultimate transition state of the reaction in which the water nucleophile attacks the anomeric center of the oxacarbenium ion-uracil anion reaction intermediate. Comparison with substrate and product structures, and the previous structure of the intermediate determined by kinetic isotope effects, reveals an exquisite example of geometric strain, least atomic motion, and electrophile migration in biological catalysis. This structure provides a rare opportunity to reconstruct the detailed structural transformations that occur along an enzymatic reaction coordinate.
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(as it appears on PubMed at http://www.pubmed.gov), where 14580190 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14580190}}
==About this Structure==
==About this Structure==
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[[Category: Dna repair]]
[[Category: Dna repair]]
[[Category: Udg]]
[[Category: Udg]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:49:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:04:27 2008''

Revision as of 05:04, 28 July 2008

Image:1q3f.png

Template:STRUCTURE 1q3f

Uracil DNA glycosylase bound to a cationic 1-aza-2'-deoxyribose-contianing DNA

Template:ABSTRACT PUBMED 14580190

About this Structure

1Q3F is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Electrostatic guidance of glycosyl cation migration along the reaction coordinate of uracil DNA glycosylase., Bianchet MA, Seiple LA, Jiang YL, Ichikawa Y, Amzel LM, Stivers JT, Biochemistry. 2003 Nov 4;42(43):12455-60. PMID:14580190

Page seeded by OCA on Mon Jul 28 08:04:27 2008

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