7zw4
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zw4 OCA], [https://pdbe.org/7zw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zw4 RCSB], [https://www.ebi.ac.uk/pdbsum/7zw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zw4 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zw4 OCA], [https://pdbe.org/7zw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zw4 RCSB], [https://www.ebi.ac.uk/pdbsum/7zw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zw4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == | + | <div style="background-color:#fffaf0;"> |
| - | + | == Publication Abstract from PubMed == | |
| + | Talin (herein referring collectively to talin 1 and 2) couples the actomyosin cytoskeleton to integrins and transmits tension to the extracellular matrix. Talin also interacts with numerous additional proteins capable of modulating the actin-integrin linkage and thus downstream mechanosignaling cascades. Here, we demonstrate that the scaffold protein Caskin2 interacts directly with the R8 domain of talin through its C-terminal LD motif. Caskin2 also associates with the WAVE regulatory complex to promote cell migration in an Abi1-dependent manner. Furthermore, we demonstrate that the Caskin2-Abi1 interaction is regulated by growth factor-induced phosphorylation of Caskin2 on serine 878. In MCF7 and UACC893 cells, which contain an amplification of CASKIN2, Caskin2 localizes in plasma membrane-associated plaques and around focal adhesions in cortical microtubule stabilization complexes. Taken together, our results identify Caskin2 as a novel talin-binding protein that might not only connect integrin-mediated adhesion to actin polymerization but could also play a role in crosstalk between integrins and microtubules. | ||
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| + | Caskin2 is a novel talin- and Abi1-binding protein that promotes cell motility.,Wang W, Atherton P, Kreft M, Te Molder L, van der Poel S, Hoekman L, Celie P, Joosten RP, Fassler R, Perrakis A, Sonnenberg A J Cell Sci. 2024 May 1;137(9):jcs262116. doi: 10.1242/jcs.262116. Epub 2024 May , 16. PMID:38587458<ref>PMID:38587458</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7zw4" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Talin 3D structures|Talin 3D structures]] | *[[Talin 3D structures|Talin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Crystal structure of Talin R7R8 domains with Caskin-2 LD-peptide
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