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1q57

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[[Image:1q57.jpg|left|200px]]
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{{STRUCTURE_1q57| PDB=1q57 | SCENE= }}
{{STRUCTURE_1q57| PDB=1q57 | SCENE= }}
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'''The Crystal Structure of the Bifunctional Primase-Helicase of Bacteriophage T7'''
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===The Crystal Structure of the Bifunctional Primase-Helicase of Bacteriophage T7===
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==Overview==
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Within minutes after infecting Escherichia coli, bacteriophage T7 synthesizes many copies of its genomic DNA. The lynchpin of the T7 replication system is a bifunctional primase-helicase that unwinds duplex DNA at the replication fork while initiating the synthesis of Okazaki fragments on the lagging strand. We have determined a 3.45 A crystal structure of the T7 primase-helicase that shows an articulated arrangement of the primase and helicase sites. The crystallized primase-helicase is a heptamer with a crown-like shape, reflecting an intimate packing of helicase domains into a ring that is topped with loosely arrayed primase domains. This heptameric isoform can accommodate double-stranded DNA in its central channel, which nicely explains its recently described DNA remodeling activity. The double-jointed structure of the primase-helicase permits a free range of motion for the primase and helicase domains that suggests how the continuous unwinding of DNA at the replication fork can be periodically coupled to Okazaki fragment synthesis.
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The line below this paragraph, {{ABSTRACT_PUBMED_14636571}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14636571 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14636571}}
==About this Structure==
==About this Structure==
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[[Category: Helicase]]
[[Category: Helicase]]
[[Category: Primase]]
[[Category: Primase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:52:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:32:06 2008''

Revision as of 04:32, 28 July 2008

Image:1q57.png

Template:STRUCTURE 1q57

The Crystal Structure of the Bifunctional Primase-Helicase of Bacteriophage T7

Template:ABSTRACT PUBMED 14636571

About this Structure

1Q57 is a Single protein structure of sequence from Enterobacteria phage t7. Full crystallographic information is available from OCA.

Reference

The crystal structure of the bifunctional primase-helicase of bacteriophage T7., Toth EA, Li Y, Sawaya MR, Cheng Y, Ellenberger T, Mol Cell. 2003 Nov;12(5):1113-23. PMID:14636571

Page seeded by OCA on Mon Jul 28 07:32:06 2008

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