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1q5x

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[[Image:1q5x.jpg|left|200px]]
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{{STRUCTURE_1q5x| PDB=1q5x | SCENE= }}
{{STRUCTURE_1q5x| PDB=1q5x | SCENE= }}
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'''Structure of OF RRAA (MENG), a protein inhibitor of RNA processing'''
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===Structure of OF RRAA (MENG), a protein inhibitor of RNA processing===
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==Overview==
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The Escherichia coli protein regulator of RNase E activity A (RraA) has recently been shown to act as a trans-acting modulator of RNA turnover in bacteria; it binds to the essential endonuclease RNase E and inhibits RNA processing in vivo and in vitro. Here, we report the 2.0A X-ray structure of RraA. The structure reveals a ring-like trimer with a central cavity of approximately 12A in diameter. Based on earlier sequence analysis, RraA had been identified as a putative S-adenosylmethionine:2-demethylmenaquinone and was annotated as MenG. However, an analysis of the RraA structure shows that the protein lacks the structural motifs usually required for methylases. Comparison of the observed fold with that of other proteins (and domains) suggests that the RraA fold is an ancient platform that has been adapted for a wide range of functions. An analysis of the amino acid sequence shows that the E.coli RraA exhibits an ancient relationship to a family of aldolases.
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The line below this paragraph, {{ABSTRACT_PUBMED_14499605}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14499605 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14499605}}
==About this Structure==
==About this Structure==
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[[Category: Antiparallel beta sheet]]
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[[Category: Parallel beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:54:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:47:25 2008''

Revision as of 02:47, 28 July 2008

Image:1q5x.png

Template:STRUCTURE 1q5x

Structure of OF RRAA (MENG), a protein inhibitor of RNA processing

Template:ABSTRACT PUBMED 14499605

About this Structure

1Q5X is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The X-ray structure of Escherichia coli RraA (MenG), A protein inhibitor of RNA processing., Monzingo AF, Gao J, Qiu J, Georgiou G, Robertus JD, J Mol Biol. 2003 Oct 3;332(5):1015-24. PMID:14499605

Page seeded by OCA on Mon Jul 28 05:47:25 2008

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