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1q5z

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{{STRUCTURE_1q5z| PDB=1q5z | SCENE= }}
{{STRUCTURE_1q5z| PDB=1q5z | SCENE= }}
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'''Crystal Structure of the C-terminal Actin Binding Domain of Salmonella Invasion Protein A (SipA)'''
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===Crystal Structure of the C-terminal Actin Binding Domain of Salmonella Invasion Protein A (SipA)===
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==Overview==
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Like many bacterial pathogens, Salmonella spp. use a type III secretion system to inject virulence proteins into host cells. The Salmonella invasion protein A (SipA) binds host actin, enhances its polymerization near adherent extracellular bacteria, and contributes to cytoskeletal rearrangements that internalize the pathogen. By combining x-ray crystallography of SipA with electron microscopy and image analysis of SipA-actin filaments, we show that SipA functions as a "molecular staple," in which a globular domain and two nonglobular "arms" mechanically stabilize the filament by tethering actin subunits in opposing strands. Deletion analysis of the tethering arms provides strong support for this model.
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(as it appears on PubMed at http://www.pubmed.gov), where 14512630 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14512630}}
==About this Structure==
==About this Structure==
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[[Category: VanLoock, M S.]]
[[Category: VanLoock, M S.]]
[[Category: Cell invasion]]
[[Category: Cell invasion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:54:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:00:21 2008''

Revision as of 17:00, 28 July 2008

Image:1q5z.png

Template:STRUCTURE 1q5z

Crystal Structure of the C-terminal Actin Binding Domain of Salmonella Invasion Protein A (SipA)

Template:ABSTRACT PUBMED 14512630

About this Structure

1Q5Z is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Salmonella SipA polymerizes actin by stapling filaments with nonglobular protein arms., Lilic M, Galkin VE, Orlova A, VanLoock MS, Egelman EH, Stebbins CE, Science. 2003 Sep 26;301(5641):1918-21. PMID:14512630

Page seeded by OCA on Mon Jul 28 20:00:21 2008

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