1q6k

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{{STRUCTURE_1q6k| PDB=1q6k | SCENE= }}
{{STRUCTURE_1q6k| PDB=1q6k | SCENE= }}
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'''Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate'''
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===Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate===
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==Overview==
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The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S(1) subsite with a series of alpha-amino aldehyde derivatives substituted at the P(1) position afforded compounds with cathepsin K IC(50)s between 52 microM and 15 nM.
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{{ABSTRACT_PUBMED_14684342}}
==About this Structure==
==About this Structure==
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[[Category: Cathepsin k]]
[[Category: Cathepsin k]]
[[Category: Catk]]
[[Category: Catk]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:55:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:48:26 2008''

Revision as of 10:48, 28 July 2008

Image:1q6k.png

Template:STRUCTURE 1q6k

Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate

Template:ABSTRACT PUBMED 14684342

About this Structure

1Q6K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Exploration of the P1 SAR of aldehyde cathepsin K inhibitors., Catalano JG, Deaton DN, Furfine ES, Hassell AM, McFadyen RB, Miller AB, Miller LR, Shewchuk LM, Willard DH Jr, Wright LL, Bioorg Med Chem Lett. 2004 Jan 5;14(1):275-8. PMID:14684342

Page seeded by OCA on Mon Jul 28 13:48:26 2008

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