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| - | [[Image:1q7d.gif|left|200px]] | + | {{Seed}} |
| | + | [[Image:1q7d.png|left|200px]] |
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| | {{STRUCTURE_1q7d| PDB=1q7d | SCENE= }} | | {{STRUCTURE_1q7d| PDB=1q7d | SCENE= }} |
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| - | '''Structure of the integrin alpha2beta1 binding collagen peptide'''
| + | ===Structure of the integrin alpha2beta1 binding collagen peptide=== |
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| - | ==Overview==
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| - | We have determined the 1.8A crystal structure of a triple helical integrin-binding collagen peptide (IBP) with sequence (Gly-Pro-Hyp)(2)-Gly-Phe-Hyp-Gly-Glu-Arg-(Gly-Pro-Hyp)(3). The central GFOGER hexapeptide is recognised specifically by the integrins alpha2beta1, alpha1beta1, alpha10beta1 and alpha11beta1. These integrin/collagen interactions are implicated in a number of key physiological processes including cell adhesion, cell growth and differentiation, and pathological states such as thrombosis and tumour metastasis. Comparison of the IBP structure with the previously determined structure of an identical collagen peptide in complex with the integrin alpha2-I domain (IBP(c)) allows the first detailed examination of collagen in a bound and an unbound state. The IBP structure shows a direct and a water-mediated electrostatic interaction between Glu and Arg side-chains from adjacent strands, but no intra-strand interactions. The interactions between IBP Glu and Arg side-chains are disrupted upon integrin binding. A comparison of IBP and IBP(c) main-chain conformation reveals the flexible nature of the triple helix backbone in the imino-poor GFOGER region. This flexibility could be important to the integrin-collagen interaction and provides a possible explanation for the unique orientation of the three GFOGER strands observed in the integrin-IBP(c) complex crystal structure.
| + | The line below this paragraph, {{ABSTRACT_PUBMED_14698296}}, adds the Publication Abstract to the page |
| | + | (as it appears on PubMed at http://www.pubmed.gov), where 14698296 is the PubMed ID number. |
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| | + | {{ABSTRACT_PUBMED_14698296}} |
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| | ==About this Structure== | | ==About this Structure== |
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| | [[Category: Integrin]] | | [[Category: Integrin]] |
| | [[Category: Triplehelix]] | | [[Category: Triplehelix]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:57:33 2008'' | + | |
| | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:19:10 2008'' |
Revision as of 20:19, 27 July 2008
Template:STRUCTURE 1q7d
Structure of the integrin alpha2beta1 binding collagen peptide
Template:ABSTRACT PUBMED 14698296
About this Structure
1Q7D is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Structure of the integrin alpha2beta1-binding collagen peptide., Emsley J, Knight CG, Farndale RW, Barnes MJ, J Mol Biol. 2004 Jan 23;335(4):1019-28. PMID:14698296
Page seeded by OCA on Sun Jul 27 23:19:10 2008
