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1q7f

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[[Image:1q7f.jpg|left|200px]]
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{{Seed}}
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[[Image:1q7f.png|left|200px]]
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{{STRUCTURE_1q7f| PDB=1q7f | SCENE= }}
{{STRUCTURE_1q7f| PDB=1q7f | SCENE= }}
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'''Brain Tumor NHL domain'''
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===Brain Tumor NHL domain===
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==Overview==
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The Brain Tumor (Brat) protein is recruited to the 3' untranslated region (UTR) of hunchback mRNA to regulate its translation. Recruitment is mediated by interactions between the Pumilio RNA-binding Puf repeats and the NHL domain of Brat, a conserved structural motif present in a large family of growth regulators. In this report, we describe the crystal structure of the Brat NHL domain and present a model of the Pumilio-Brat complex derived from in silico docking experiments and supported by mutational analysis of the protein-protein interface. A key feature of the model is recognition of the outer, convex surface of the Pumilio Puf domain by the top, electropositive face of the six-bladed Brat beta-propeller. In particular, an extended loop in Puf repeat 8 fits in the entrance to the central channel of the Brat beta-propeller. Together, these interactions are likely to be prototypic of the recruitment strategies of other NHL-containing proteins in development.
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The line below this paragraph, {{ABSTRACT_PUBMED_14561773}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14561773 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14561773}}
==About this Structure==
==About this Structure==
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[[Category: Nhl domain]]
[[Category: Nhl domain]]
[[Category: Nhl repeat]]
[[Category: Nhl repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:57:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:59:03 2008''

Revision as of 10:59, 27 July 2008

Image:1q7f.png

Template:STRUCTURE 1q7f

Brain Tumor NHL domain

Template:ABSTRACT PUBMED 14561773

About this Structure

1Q7F is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Model of the brain tumor-Pumilio translation repressor complex., Edwards TA, Wilkinson BD, Wharton RP, Aggarwal AK, Genes Dev. 2003 Oct 15;17(20):2508-13. PMID:14561773

Page seeded by OCA on Sun Jul 27 13:59:03 2008

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