1q7s

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{{STRUCTURE_1q7s| PDB=1q7s | SCENE= }}
{{STRUCTURE_1q7s| PDB=1q7s | SCENE= }}
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'''Crystal structure of bit1'''
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===Crystal structure of bit1===
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==Overview==
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Peptidyl-tRNA hydrolase (Pth) activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two different enzymes have been reported to encode such activity, Pth present in bacteria and eukaryotes and Pth2 present in archaea and eukaryotes. Here we report the crystallographic structure of the Homo sapiens Pth2 at a 2.0-A resolution as well as its catalytic properties. In contrast to the structure of Escherichia coli Pth, H. sapiens Pth2 has an alpha/beta fold with a four-stranded antiparallel beta-sheet in its core surrounded by two alpha-helices on each side. This arrangement of secondary structure elements generates a fold not previously reported. Its catalytic efficiency is comparable with that reported for the archaeal Sulfolobus solfataricus Pth2 and higher than that of the bacterial E. coli Pth. Several lines of evidence target the active site to two close loops with highly conserved residues. This active site architecture is unrelated to that of E. coli Pth. In addition, intermolecular contacts in the crystal asymmetric unit cell suggest a likely surface for protein-protein interactions related to the Pth2-mediated apoptosis.
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The line below this paragraph, {{ABSTRACT_PUBMED_14660562}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14660562 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14660562}}
==About this Structure==
==About this Structure==
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[[Category: Waas, W F.]]
[[Category: Waas, W F.]]
[[Category: Apoptosis]]
[[Category: Apoptosis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:58:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:24:27 2008''

Revision as of 23:24, 27 July 2008

Image:1q7s.png

Template:STRUCTURE 1q7s

Crystal structure of bit1

Template:ABSTRACT PUBMED 14660562

About this Structure

1Q7S is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity., De Pereda JM, Waas WF, Jan Y, Ruoslahti E, Schimmel P, Pascual J, J Biol Chem. 2004 Feb 27;279(9):8111-5. Epub 2003 Dec 5. PMID:14660562

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