1q8m

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{{Seed}}
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{{STRUCTURE_1q8m| PDB=1q8m | SCENE= }}
{{STRUCTURE_1q8m| PDB=1q8m | SCENE= }}
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'''Crystal structure of the human myeloid cell activating receptor TREM-1'''
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===Crystal structure of the human myeloid cell activating receptor TREM-1===
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==Overview==
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Triggering receptors expressed on myeloid cells (TREM) are a family of recently discovered receptors that play important roles in innate immune responses, such as to activate inflammatory responses and to contribute to septic shock in response to microbial-mediated infections. To date, two TREM receptors in human and several homologs in mice have been identified. We report the 2.6 A resolution crystal structure of the extracellular domain of human TREM-1. The overall fold of the receptor resembles that of a V-type immunoglobulin domain with differences primarily located in the N-terminal strand. TREM-1 forms a "head-to-tail" dimer with 4100 A(2) interface area that is partially mediated by a domain swapping between the first strands. This mode of dimer formation is different from the "head-to-head" dimerization that existed in V(H)V(L) domains of antibodies or V domains of T cell receptors. As a result, the dimeric TREM-1 most likely contains two distinct ligand binding sites.
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The line below this paragraph, {{ABSTRACT_PUBMED_14656437}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14656437 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14656437}}
==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin-like]]
[[Category: Immunoglobulin-like]]
[[Category: V-type ig-like domain]]
[[Category: V-type ig-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:00:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:29:21 2008''

Revision as of 07:29, 28 July 2008

Image:1q8m.png

Template:STRUCTURE 1q8m

Crystal structure of the human myeloid cell activating receptor TREM-1

Template:ABSTRACT PUBMED 14656437

About this Structure

1Q8M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human myeloid cell activating receptor TREM-1., Radaev S, Kattah M, Rostro B, Colonna M, Sun PD, Structure. 2003 Dec;11(12):1527-35. PMID:14656437

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