1q8r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1q8r.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1q8r.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1q8r| PDB=1q8r | SCENE= }}
{{STRUCTURE_1q8r| PDB=1q8r | SCENE= }}
-
'''Structure of E.coli RusA Holliday junction resolvase'''
+
===Structure of E.coli RusA Holliday junction resolvase===
-
==Overview==
+
<!--
-
Holliday junction resolution performed by a variety of structure-specific endonucleases is a key step in DNA recombination and repair. It is believed that all resolvases carry out their reaction chemistries in a similar fashion, utilizing a divalent cation to facilitate the hydrolysis of the phosphodiester backbone of the DNA, but their architecture varies. To date, with the exception of bacteriophage T4 endonuclease VII, each of the known resolvase enzyme structures has been categorized into one of two families: the integrases and the nucleases. We have now determined the structure of the Escherichia coli RusA Holliday junction resolvase, which reveals a fourth structural class for these enzymes. The structure suggests that dimer formation is essential for Mg(2+) cation binding and hence catalysis and that like the other resolvases, RusA distorts its Holliday junction target upon binding. Key residues identified by mutagenesis experiments are well positioned to interact with the DNA.
+
The line below this paragraph, {{ABSTRACT_PUBMED_14656440}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 14656440 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_14656440}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Extended mixed beta sheet]]
[[Category: Extended mixed beta sheet]]
[[Category: Recombination,hydrolase]]
[[Category: Recombination,hydrolase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:00:24 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:24:46 2008''

Revision as of 20:24, 28 July 2008

Image:1q8r.png

Template:STRUCTURE 1q8r

Structure of E.coli RusA Holliday junction resolvase

Template:ABSTRACT PUBMED 14656440

About this Structure

1Q8R is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The structure of Escherichia coli RusA endonuclease reveals a new Holliday junction DNA binding fold., Rafferty JB, Bolt EL, Muranova TA, Sedelnikova SE, Leonard P, Pasquo A, Baker PJ, Rice DW, Sharples GJ, Lloyd RG, Structure. 2003 Dec;11(12):1557-67. PMID:14656440

Page seeded by OCA on Mon Jul 28 23:24:46 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1q8r"
Personal tools