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1q93

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[[Image:1q93.gif|left|200px]]
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{{STRUCTURE_1q93| PDB=1q93 | SCENE= }}
{{STRUCTURE_1q93| PDB=1q93 | SCENE= }}
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'''Crystal structure of a mutant of the sarcin/ricin domain from rat 28S rRNA'''
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===Crystal structure of a mutant of the sarcin/ricin domain from rat 28S rRNA===
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==Overview==
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Bulged-G motifs are ubiquitous internal RNA loops that provide specific recognition sites for proteins and RNAs. To establish the common and distinctive features of the motif we determined the structures of three variants and compared them with related structures. The variants are 27-nt mimics of the sarcin/ricin loop (SRL) from Escherichia coli 23S ribosomal RNA that is an essential part of the binding site for elongation factors (EFs). The wild-type SRL has now been determined at 1.04 A resolution, supplementing data obtained before at 1.11 A and allowing the first calculation of coordinate error for an RNA motif. The other two structures, having a viable (C2658U*G2663A) or a lethal mutation (C2658G*G2663C), were determined at 1.75 and 2.25 A resolution, respectively. Comparisons reveal that bulged-G motifs have a common hydration and geometry, with flexible junctions at flanking structural elements. Six conserved nucleotides preserve the fold of the motif; the remaining seven to nine vary in sequence and alter contacts in both grooves. Differences between accessible functional groups of the lethal mutation and those of the viable mutation and wild-type SRL may account for the impaired elongation factor binding to ribosomes with the C2658G*G2663C mutation and may underlie the lethal phenotype.
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The line below this paragraph, {{ABSTRACT_PUBMED_14627814}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14627814 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14627814}}
==About this Structure==
==About this Structure==
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[[Category: Sarcin/ricin domain]]
[[Category: Sarcin/ricin domain]]
[[Category: Stem-loop]]
[[Category: Stem-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:01:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:59:58 2008''

Revision as of 17:00, 28 July 2008

Image:1q93.png

Template:STRUCTURE 1q93

Crystal structure of a mutant of the sarcin/ricin domain from rat 28S rRNA

Template:ABSTRACT PUBMED 14627814

About this Structure

1Q93 is a Single protein structure. Full crystallographic information is available from OCA.

Reference

The common and the distinctive features of the bulged-G motif based on a 1.04 A resolution RNA structure., Correll CC, Beneken J, Plantinga MJ, Lubbers M, Chan YL, Nucleic Acids Res. 2003 Dec 1;31(23):6806-18. PMID:14627814

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