1q9j

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{{STRUCTURE_1q9j| PDB=1q9j | SCENE= }}
{{STRUCTURE_1q9j| PDB=1q9j | SCENE= }}
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'''Structure of polyketide synthase associated protein 5 from Mycobacterium tuberculosis'''
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===Structure of polyketide synthase associated protein 5 from Mycobacterium tuberculosis===
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==Overview==
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Polyketide-associated protein A5 (PapA5) is an acyltransferase that is involved in production of phthiocerol and phthiodiolone dimycocerosate esters, a class of virulence-enhancing lipids produced by Mycobacterium tuberculosis. Structural analysis of PapA5 at 2.75-A resolution reveals a two-domain structure that shares unexpected similarity to structures of chloramphenicol acetyltransferase, dihydrolipoyl transacetylase, carnitine acetyltransferase, and VibH, a non-ribosomal peptide synthesis condensation enzyme. The PapA5 active site includes conserved histidine and aspartic acid residues that are critical to PapA5 acyltransferase activity. PapA5 catalyzes acyl transfer reactions on model substrates that contain long aliphatic carbon chains, and two hydrophobic channels were observed linking the PapA5 surface to the active site with properties consistent with these biochemical activities and substrate preferences. An additional alpha helix not observed in other acyltransferase structures blocks the putative entrance into the PapA5 active site, indicating that conformational changes may be associated with PapA5 activity. PapA5 represents the first structure solved for a protein involved in polyketide synthesis in Mycobacteria.
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{{ABSTRACT_PUBMED_15123643}}
==About this Structure==
==About this Structure==
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[[Category: Psi]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:02:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:36:47 2008''

Revision as of 01:36, 29 July 2008

Image:1q9j.png

Template:STRUCTURE 1q9j

Structure of polyketide synthase associated protein 5 from Mycobacterium tuberculosis

Template:ABSTRACT PUBMED 15123643

About this Structure

1Q9J is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Crystal structure of PapA5, a phthiocerol dimycocerosyl transferase from Mycobacterium tuberculosis., Buglino J, Onwueme KC, Ferreras JA, Quadri LE, Lima CD, J Biol Chem. 2004 Jul 16;279(29):30634-42. Epub 2004 May 3. PMID:15123643

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