1qbj

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{{STRUCTURE_1qbj| PDB=1qbj | SCENE= }}
{{STRUCTURE_1qbj| PDB=1qbj | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE ZALPHA Z-DNA COMPLEX'''
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===CRYSTAL STRUCTURE OF THE ZALPHA Z-DNA COMPLEX===
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==Overview==
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The editing enzyme double-stranded RNA adenosine deaminase includes a DNA binding domain, Zalpha, which is specific for left-handed Z-DNA. The 2.1 angstrom crystal structure of Zalpha complexed to DNA reveals that the substrate is in the left-handed Z conformation. The contacts between Zalpha and Z-DNA are made primarily with the "zigzag" sugar-phosphate backbone, which provides a basis for the specificity for the Z conformation. A single base contact is observed to guanine in the syn conformation, characteristic of Z-DNA. Intriguingly, the helix-turn-helix motif, frequently used to recognize B-DNA, is used by Zalpha to contact Z-DNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 10364558 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10364558}}
==About this Structure==
==About this Structure==
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[[Category: Schwartz, T.]]
[[Category: Schwartz, T.]]
[[Category: Protein/z-dna complex]]
[[Category: Protein/z-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:06:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:50:14 2008''

Revision as of 04:50, 28 July 2008

Image:1qbj.png

Template:STRUCTURE 1qbj

CRYSTAL STRUCTURE OF THE ZALPHA Z-DNA COMPLEX

Template:ABSTRACT PUBMED 10364558

About this Structure

1QBJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA., Schwartz T, Rould MA, Lowenhaupt K, Herbert A, Rich A, Science. 1999 Jun 11;284(5421):1841-5. PMID:10364558

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