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1qc1

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{{Seed}}
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{{STRUCTURE_1qc1| PDB=1qc1 | SCENE= }}
{{STRUCTURE_1qc1| PDB=1qc1 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE SELF-FITTED B-DNA DECAMER D(CCGCCGGCGG)'''
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===CRYSTAL STRUCTURE OF THE SELF-FITTED B-DNA DECAMER D(CCGCCGGCGG)===
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==Overview==
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Groove-backbone interaction is a natural and biologically relevant mechanism for the specific assembly of B-DNA double helices. Crystal engineering and crystal packing analysis of oligonucleotides of different sizes and sequences reveal that the sequence-dependent self-fitting of B-DNA helices is a dominant constraint for their ordered assembly. It can override the other intermolecular interactions and impose the overall geometry of the packing. Analysis of experimental examples of architectural motifs formed by the geometric combination of self-fitted DNA segments leads to general rules for DNA assembly. Like a directing piece for a supramolecular 'construction set', the double helix imposes a limited number of geometric solutions. These basic architectural constraints could direct, in a codified manner, the formation of higher-order structures. DNA architectural motifs exhibit new structural and electrostatic properties which could have some implications for their molecular recognition by proteins acting on DNA.
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The line below this paragraph, {{ABSTRACT_PUBMED_8026458}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8026458 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8026458}}
==About this Structure==
==About this Structure==
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[[Category: B-dna double-helix]]
[[Category: B-dna double-helix]]
[[Category: Dna-dna recognition]]
[[Category: Dna-dna recognition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:06:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:19:25 2008''

Revision as of 04:19, 28 July 2008

Image:1qc1.png

Template:STRUCTURE 1qc1

CRYSTAL STRUCTURE OF THE SELF-FITTED B-DNA DECAMER D(CCGCCGGCGG)

Template:ABSTRACT PUBMED 8026458

About this Structure

Full crystallographic information is available from OCA.

Reference

DNA self-fitting: the double helix directs the geometry of its supramolecular assembly., Timsit Y, Moras D, EMBO J. 1994 Jun 15;13(12):2737-46. PMID:8026458

Page seeded by OCA on Mon Jul 28 07:19:25 2008

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