1qc8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1qc8.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1qc8.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1qc8| PDB=1qc8 | SCENE= }}
{{STRUCTURE_1qc8| PDB=1qc8 | SCENE= }}
-
'''NMR STRUCTURE OF TAU EXON 10 SPLICING REGULATORY ELEMENT RNA'''
+
===NMR STRUCTURE OF TAU EXON 10 SPLICING REGULATORY ELEMENT RNA===
-
==Overview==
+
<!--
-
Coding region and intronic mutations in the tau gene cause frontotemporal dementia and parkinsonism linked to chromosome 17. Intronic mutations and some missense mutations increase splicing in of exon 10, leading to an increased ratio of four-repeat to three-repeat tau isoforms. Secondary structure predictions have led to the proposal that intronic mutations and one missense mutation destabilize a putative RNA stem-loop structure located close to the splice-donor site of the intron after exon 10. We have determined the three-dimensional structure of this tau exon 10 splicing regulatory element RNA by NMR spectroscopy. We show that it forms a stable, folded stem-loop structure whose thermodynamic stability is reduced by frontotemporal dementia and parkinsonism linked to chromosome 17 mutations and increased by compensatory mutations. By exon trapping, the reduction in thermodynamic stability is correlated with increased splicing in of exon 10.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10393977}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10393977 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10393977}}
==About this Structure==
==About this Structure==
-
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QC8 OCA].
+
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QC8 OCA].
==Reference==
==Reference==
Line 30: Line 34:
[[Category: Stem-loop rna structure]]
[[Category: Stem-loop rna structure]]
[[Category: Tau gene exon 10]]
[[Category: Tau gene exon 10]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:07:11 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:56:11 2008''

Revision as of 06:56, 28 July 2008

Image:1qc8.png

Template:STRUCTURE 1qc8

NMR STRUCTURE OF TAU EXON 10 SPLICING REGULATORY ELEMENT RNA

Template:ABSTRACT PUBMED 10393977

About this Structure

Full experimental information is available from OCA.

Reference

Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17., Varani L, Hasegawa M, Spillantini MG, Smith MJ, Murrell JR, Ghetti B, Klug A, Goedert M, Varani G, Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8229-34. PMID:10393977

Page seeded by OCA on Mon Jul 28 09:56:11 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qc8"
Personal tools