8ijq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8ijq is ON HOLD until 2025-05-27
+
==The cryo-EM structure of human sphingomyelin synthase-related protein in complex with ceramide==
-
 
+
<StructureSection load='8ijq' size='340' side='right'caption='[[8ijq]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8ijq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IJQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IJQ FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.45&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16C:N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE'>16C</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ijq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ijq OCA], [https://pdbe.org/8ijq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ijq RCSB], [https://www.ebi.ac.uk/pdbsum/8ijq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ijq ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SAMD8_HUMAN SAMD8_HUMAN] Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.<ref>PMID:19506037</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Cao Y]]
 +
[[Category: Chen Y]]
 +
[[Category: Hu K]]
 +
[[Category: Yao D]]
 +
[[Category: Zhang Q]]
 +
[[Category: Zhou L]]

Revision as of 09:37, 1 March 2024

The cryo-EM structure of human sphingomyelin synthase-related protein in complex with ceramide

PDB ID 8ijq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8ijq"
Personal tools