8y8v

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Current revision (06:25, 19 March 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8y8v is ON HOLD until Paper Publication
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==Cryo-EM structure of AQP7 in POPC nanodisc==
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<StructureSection load='8y8v' size='340' side='right'caption='[[8y8v]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8y8v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Y8V FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.49&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P5S:O-[(R)-{[(2R)-2,3-BIS(OCTADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-L-SERINE'>P5S</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8y8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y8v OCA], [https://pdbe.org/8y8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y8v RCSB], [https://www.ebi.ac.uk/pdbsum/8y8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y8v ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AQP7_HUMAN AQP7_HUMAN] Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).[UniProtKB:O54794]<ref>PMID:11952783</ref> <ref>PMID:30420639</ref> <ref>PMID:30423801</ref> <ref>PMID:9405233</ref> [https://www.uniprot.org/uniprot/GFP_AEQVI GFP_AEQVI] Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Aequorea victoria]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Fujiyosh Y]]
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[[Category: Kamegawa A]]
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[[Category: Kozai D]]
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[[Category: Nishikawa K]]
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[[Category: Suzuki H]]
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[[Category: Suzuki S]]

Current revision

Cryo-EM structure of AQP7 in POPC nanodisc

PDB ID 8y8v

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