1qdp

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{{STRUCTURE_1qdp| PDB=1qdp | SCENE= }}
{{STRUCTURE_1qdp| PDB=1qdp | SCENE= }}
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'''SOLUTION STRUCTURE OF ROBUSTOXIN, THE LETHAL NEUROTOXIN FROM THE FUNNEL WEB SPIDER ATRAX ROBUSTUS, NMR, 20 STRUCTURES'''
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===SOLUTION STRUCTURE OF ROBUSTOXIN, THE LETHAL NEUROTOXIN FROM THE FUNNEL WEB SPIDER ATRAX ROBUSTUS, NMR, 20 STRUCTURES===
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==Overview==
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The solution structure of robustoxin, the lethal neurotoxin from the Sydney funnel-web spider Atrax robustus, has been determined from 2D 1H NMR data. Robustoxin is a polypeptide of 42 residues cross-linked by four disulphide bonds, the connectivities of which were determined from NMR data and trial structure calculations to be 1-15, 8-20, 14-31 and 16-42 (a 1-4/2-6/3-7/5-8 pattern). The structure consists of a small three-stranded, anti-parallel beta-sheet and a series of interlocking gamma-turns at the C-terminus. It also contains a cystine knot, thus placing it in the inhibitor cystine knot motif family of structures, which includes the omega-conotoxins and a number of plant and animal toxins and protease inhibitors. Robustoxin contains three distinct charged patches on its surface, and an extended loop that includes several aromatic and non-polar residues. Both of these structural features may play a role in its binding to the voltage-gated sodium channel.
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(as it appears on PubMed at http://www.pubmed.gov), where 9428632 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9428632}}
==About this Structure==
==About this Structure==
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1QDP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Atrax_robustus Atrax robustus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QDP OCA].
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1QDP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Atrax_robustus Atrax robustus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QDP OCA].
==Reference==
==Reference==
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[[Category: Sodium channel modulator]]
[[Category: Sodium channel modulator]]
[[Category: Venom]]
[[Category: Venom]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:10:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:28:53 2008''

Revision as of 07:28, 28 July 2008

Image:1qdp.png

Template:STRUCTURE 1qdp

SOLUTION STRUCTURE OF ROBUSTOXIN, THE LETHAL NEUROTOXIN FROM THE FUNNEL WEB SPIDER ATRAX ROBUSTUS, NMR, 20 STRUCTURES

Template:ABSTRACT PUBMED 9428632

About this Structure

1QDP is a Single protein structure of sequence from Atrax robustus. Full experimental information is available from OCA.

Reference

Solution structure of robustoxin, the lethal neurotoxin from the funnel-web spider Atrax robustus., Pallaghy PK, Alewood D, Alewood PF, Norton RS, FEBS Lett. 1997 Dec 15;419(2-3):191-6. PMID:9428632

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