1qet

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{{Seed}}
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{{STRUCTURE_1qet| PDB=1qet | SCENE= }}
{{STRUCTURE_1qet| PDB=1qet | SCENE= }}
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'''TANDEM GU MISMATCHES IN RNA, NMR, 30 STRUCTURES'''
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===TANDEM GU MISMATCHES IN RNA, NMR, 30 STRUCTURES===
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==Overview==
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The symmetric, tandem GU mismatch motifs, and , which only differ in the mismatch order, have an average difference in thermodynamic stability of 2 kcal/mol at 37 degrees C. Thermodynamic studies of duplexes containing these motifs indicate the effect is largely localized to the mismatches and adjacent base pairs. The three-dimensional structures of two representative duplexes, (rGGAGUUCC)2 and (rGGAUGUCC)2, were determined by two-dimensional NMR and a simulated annealing protocol. Local deviations are similar to other intrahelical GU mismatches with little effect on backbone torsion angles and a slight overtwisting between the base pair 5' of the G of the mismatch and the mismatch itself. Comparisons of the resulting stacking patterns along with electrostatic potential maps suggest that interactions between highly negative electrostatic regions between base pairs may play a role in the observed thermodynamic differences.
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(as it appears on PubMed at http://www.pubmed.gov), where 9201950 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9201950}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QET OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QET OCA].
==Reference==
==Reference==
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[[Category: G:u mismatch]]
[[Category: G:u mismatch]]
[[Category: Ribonucleic acid]]
[[Category: Ribonucleic acid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:10:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:37:05 2008''

Revision as of 01:37, 29 July 2008

Image:1qet.png

Template:STRUCTURE 1qet

TANDEM GU MISMATCHES IN RNA, NMR, 30 STRUCTURES

Template:ABSTRACT PUBMED 9201950

About this Structure

Full experimental information is available from OCA.

Reference

Investigation of the structural basis for thermodynamic stabilities of tandem GU wobble pairs: NMR structures of (rGGAGUUCC)2 and (rGGAUGUCC)2., McDowell JA, He L, Chen X, Turner DH, Biochemistry. 1997 Jul 1;36(26):8030-8. PMID:9201950

Page seeded by OCA on Tue Jul 29 04:37:05 2008

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