1qfh

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{{STRUCTURE_1qfh| PDB=1qfh | SCENE= }}
{{STRUCTURE_1qfh| PDB=1qfh | SCENE= }}
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'''DIMERIZATION OF GELATION FACTOR FROM DICTYOSTELIUM DISCOIDEUM: CRYSTAL STRUCTURE OF ROD DOMAINS 5 AND 6'''
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===DIMERIZATION OF GELATION FACTOR FROM DICTYOSTELIUM DISCOIDEUM: CRYSTAL STRUCTURE OF ROD DOMAINS 5 AND 6===
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==Overview==
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Gelation factor (ABP120) is one of the principal actin-cross-linking proteins of Dictyostelium discoideum. The extended molecule has an N-terminal 250-residue actin-binding domain and a rod constructed from six 100-residue repeats that have an Ig fold. The ability to dimerize is crucial to the actin cross-linking function of gelation factor and is mediated by the rod in which the two chains are arranged in an antiparallel fashion. We report the 2.2 A resolution crystal structure of rod domains 5 and 6, which shows that dimerization is mediated primarily by rod domain 6 and is the result of a double edge-to-edge extension of beta-sheets. Thus, contrary to earlier proposals, the chains of the dimeric gelation factor molecule overlap only within domain 6, and domains 1-5 do not pair with domains from the other chain. This information allows construction of a model of the gelation factor molecule and suggests how the chains in the related molecule filamin (ABP280) may interact.
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(as it appears on PubMed at http://www.pubmed.gov), where 10467095 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10467095}}
==About this Structure==
==About this Structure==
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[[Category: Gelation factor]]
[[Category: Gelation factor]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:12:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:44:12 2008''

Revision as of 13:44, 27 July 2008

Image:1qfh.png

Template:STRUCTURE 1qfh

DIMERIZATION OF GELATION FACTOR FROM DICTYOSTELIUM DISCOIDEUM: CRYSTAL STRUCTURE OF ROD DOMAINS 5 AND 6

Template:ABSTRACT PUBMED 10467095

About this Structure

1QFH is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

Structural basis for dimerization of the Dictyostelium gelation factor (ABP120) rod., McCoy AJ, Fucini P, Noegel AA, Stewart M, Nat Struct Biol. 1999 Sep;6(9):836-41. PMID:10467095

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