1qfo

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{{STRUCTURE_1qfo| PDB=1qfo | SCENE= }}
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'''N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE) IN COMPLEX WITH 3'SIALYLLACTOSE'''
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===N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE) IN COMPLEX WITH 3'SIALYLLACTOSE===
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==Overview==
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The structure of the functional N-terminal domain from the extracellular region of the cell surface receptor sialoadhesin has been determined in complex with the oligosaccharide 3' sialyllactose. This provides structural information for the siglec family of proteins. The structure conforms to the V-set immunoglobulin-like fold but contains several distinctive features, including an intra-beta sheet disulphide and a splitting of the standard beta strand G into two shorter strands. These novel features appear important in adapting the V-set fold for sialic acid-mediated recognition. Analysis of the complex with 3'sialyllactose highlights three residues, conserved throughout the siglec family, as key features of the sialic acid-binding template. The complex is representative of the functional recognition interaction with carbohydrate and as such provides detailed information for a heterotypic cell adhesion interaction.
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{{ABSTRACT_PUBMED_9660955}}
==About this Structure==
==About this Structure==
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[[Category: Carbohydrate binding]]
[[Category: Carbohydrate binding]]
[[Category: Immunoglobulin superfamily]]
[[Category: Immunoglobulin superfamily]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:12:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:05:00 2008''

Revision as of 17:05, 28 July 2008

Image:1qfo.png

Template:STRUCTURE 1qfo

N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE) IN COMPLEX WITH 3'SIALYLLACTOSE

Template:ABSTRACT PUBMED 9660955

About this Structure

1QFO is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the N-terminal domain of sialoadhesin in complex with 3' sialyllactose at 1.85 A resolution., May AP, Robinson RC, Vinson M, Crocker PR, Jones EY, Mol Cell. 1998 Apr;1(5):719-28. PMID:9660955

Page seeded by OCA on Mon Jul 28 20:05:00 2008

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