1qfs

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[[Image:1qfs.gif|left|200px]]
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{{Seed}}
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[[Image:1qfs.png|left|200px]]
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{{STRUCTURE_1qfs| PDB=1qfs | SCENE= }}
{{STRUCTURE_1qfs| PDB=1qfs | SCENE= }}
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'''PROLYL OLIGOPEPTIDASE FROM PORCINE MUSCLE WITH COVALENTLY BOUND INHIBITOR Z-PRO-PROLINAL'''
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===PROLYL OLIGOPEPTIDASE FROM PORCINE MUSCLE WITH COVALENTLY BOUND INHIBITOR Z-PRO-PROLINAL===
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==Overview==
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Prolyl oligopeptidase is a large cytosolic enzyme that belongs to a new class of serine peptidases. The enzyme is involved in the maturation and degradation of peptide hormones and neuropeptides, which relate to the induction of amnesia. The 1.4 A resolution crystal structure is presented here. The enzyme contains a peptidase domain with an alpha/beta hydrolase fold, and its catalytic triad (Ser554, His680, Asp641) is covered by the central tunnel of an unusual beta propeller. This domain makes prolyl oligopeptidase an oligopeptidase by excluding large structured peptides from the active site. In this way, the propeller protects larger peptides and proteins from proteolysis in the cytosol. The structure is also obtained with a transition state inhibitor, which may facilitate drug design to treat memory disorders.
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The line below this paragraph, {{ABSTRACT_PUBMED_9695945}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9695945 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9695945}}
==About this Structure==
==About this Structure==
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[[Category: Beta-propeller]]
[[Category: Beta-propeller]]
[[Category: Prolyl oligopeptidase]]
[[Category: Prolyl oligopeptidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:12:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:01:44 2008''

Revision as of 08:01, 28 July 2008

Image:1qfs.png

Template:STRUCTURE 1qfs

PROLYL OLIGOPEPTIDASE FROM PORCINE MUSCLE WITH COVALENTLY BOUND INHIBITOR Z-PRO-PROLINAL

Template:ABSTRACT PUBMED 9695945

About this Structure

1QFS is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis., Fulop V, Bocskei Z, Polgar L, Cell. 1998 Jul 24;94(2):161-70. PMID:9695945

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