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1qg9

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[[Image:1qg9.gif|left|200px]]
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[[Image:1qg9.png|left|200px]]
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{{STRUCTURE_1qg9| PDB=1qg9 | SCENE= }}
{{STRUCTURE_1qg9| PDB=1qg9 | SCENE= }}
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'''SECOND REPEAT (IS2MIC) FROM VOLTAGE-GATED SODIUM CHANNEL'''
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===SECOND REPEAT (IS2MIC) FROM VOLTAGE-GATED SODIUM CHANNEL===
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==Overview==
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Peptides representing transmembrane regions of the alpha-subunit of the voltage-gated sodium channel were synthesised and their structures analysed, using 1H NMR and CD, in trifluoroethanol and in dodecylphosphocholine micelles. Sequence analysis suggests that the channel has six regions, S1 to S6, predicted to span the membrane in four homologous domains, designated, I, II, III and IV. Presented here are studies of representatives examples of possible single spanning segments (IS2, IS4, IVS4) and a double spanning segment, IS34, composed of segments IS3 and IS4. In addition, we investigated ISlink56, the putative linker region between segments IS5 and IS6. All of the peptides were found to have predominantly alpha-helical structures in both solvent systems. There was some evidence for bending of the longer helices but there was no discernible evidence for well-defined tertiary structure.
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The line below this paragraph, {{ABSTRACT_PUBMED_8637001}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8637001 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8637001}}
==About this Structure==
==About this Structure==
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1QG9 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QG9 OCA].
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1QG9 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QG9 OCA].
==Reference==
==Reference==
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[[Category: Nmr structure]]
[[Category: Nmr structure]]
[[Category: Transmembrane sodium channel]]
[[Category: Transmembrane sodium channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:14:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:11:41 2008''

Revision as of 17:11, 27 July 2008

Image:1qg9.png

Template:STRUCTURE 1qg9

SECOND REPEAT (IS2MIC) FROM VOLTAGE-GATED SODIUM CHANNEL

Template:ABSTRACT PUBMED 8637001

About this Structure

1QG9 is a Single protein structure. Full experimental information is available from OCA.

Reference

Structural studies of synthetic peptides dissected from the voltage-gated sodium channel., Doak DG, Mulvey D, Kawaguchi K, Villalain J, Campbell ID, J Mol Biol. 1996 May 17;258(4):672-87. PMID:8637001

Page seeded by OCA on Sun Jul 27 20:11:41 2008

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