1qgb

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[[Image:1qgb.jpg|left|200px]]
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[[Image:1qgb.png|left|200px]]
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{{STRUCTURE_1qgb| PDB=1qgb | SCENE= }}
{{STRUCTURE_1qgb| PDB=1qgb | SCENE= }}
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'''SOLUTION STRUCTURE OF THE N-TERMINAL F1 MODULE PAIR FROM HUMAN FIBRONECTIN'''
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===SOLUTION STRUCTURE OF THE N-TERMINAL F1 MODULE PAIR FROM HUMAN FIBRONECTIN===
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==Overview==
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Multiple sites within the N-terminal domain (1-5F1) of fibronectin have been implicated previously in fibronectin matrix assembly, heparin binding, and binding to cell surface proteins of pathogenic bacteria. The solution structure of 1F1(2)F1, the N-terminal F1 module pair from human fibronectin, has been determined using NMR spectroscopy. Both modules in the pair conform to the F1 consensus fold. In 4F1(5)F1, the only other F1 module pair structure available, there is a well-defined intermodule interface; in 1F1(2)F1, however, there is no detectable interface between the modules. Comparison of the backbone 15N-{1H} NOE values for both module pairs confirms that the longer intermodule sequence in 1F1(2)F1 is flexible and that the stabilization of the 4F1 C-D loop observed in 4F1(5)F1, as a result of the intermodule interface, is not observed in 1F1(2)F1.
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The line below this paragraph, {{ABSTRACT_PUBMED_10387076}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10387076 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10387076}}
==About this Structure==
==About this Structure==
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1QGB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QGB OCA].
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1QGB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QGB OCA].
==Reference==
==Reference==
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[[Category: Potts, J R.]]
[[Category: Potts, J R.]]
[[Category: Fibronectin type 1 module pair]]
[[Category: Fibronectin type 1 module pair]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:14:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:06:55 2008''

Revision as of 08:06, 28 July 2008

Image:1qgb.png

Template:STRUCTURE 1qgb

SOLUTION STRUCTURE OF THE N-TERMINAL F1 MODULE PAIR FROM HUMAN FIBRONECTIN

Template:ABSTRACT PUBMED 10387076

About this Structure

1QGB is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the N-terminal F1 module pair from human fibronectin., Potts JR, Bright JR, Bolton D, Pickford AR, Campbell ID, Biochemistry. 1999 Jun 29;38(26):8304-12. PMID:10387076

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