1qgk

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[[Image:1qgk.gif|left|200px]]
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[[Image:1qgk.png|left|200px]]
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==Overview==
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{{ABSTRACT_10353244}}
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Cytosolic proteins bearing a classical nuclear localization signal enter the nucleus bound to a heterodimer of importin-alpha and importin-beta (also called karyopherin-alpha and -beta). The formation of this heterodimer involves the importin-beta-binding (IBB) domain of importin-alpha, a highly basic amino-terminal region of roughly 40 amino-acid residues. Here we report the crystal structure of human importin-beta bound to the IBB domain of importin-alpha, determined at 2.5 A and 2.3 A resolution in two crystal forms. Importin-beta consists of 19 tandemly repeated HEAT motifs and wraps intimately around the IBB domain. The association involves two separate regions of importin-beta, recognizing structurally distinct parts of the IBB domain: an amino-terminal extended moiety and a carboxy-terminal helix. The structure indicates that significant conformational changes occur when importin-beta binds or releases the IBB domain domain and suggests how dissociation of the importin-alpha/beta heterodimer may be achieved upon nuclear entry.
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==About this Structure==
==About this Structure==
1QGK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1QGK with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb85_1.html Importins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QGK OCA].
1QGK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1QGK with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb85_1.html Importins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QGK OCA].
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==Reference==
 
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Structure of importin-beta bound to the IBB domain of importin-alpha., Cingolani G, Petosa C, Weis K, Muller CW, Nature. 1999 May 20;399(6733):221-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10353244 10353244]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Importins]]
[[Category: Importins]]
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[[Category: Nuclear import]]
[[Category: Nuclear import]]
[[Category: Transport receptor]]
[[Category: Transport receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:14:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:51:49 2008''

Revision as of 14:51, 26 June 2008

Image:1qgk.png

Template:STRUCTURE 1qgk

STRUCTURE OF IMPORTIN BETA BOUND TO THE IBB DOMAIN OF IMPORTIN ALPHA


Template:ABSTRACT 10353244

About this Structure

1QGK is a Protein complex structure of sequences from Homo sapiens. The following page contains interesting information on the relation of 1QGK with [Importins]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:51:49 2008

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