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1qh2

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[[Image:1qh2.jpg|left|200px]]
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[[Image:1qh2.png|left|200px]]
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{{STRUCTURE_1qh2| PDB=1qh2 | SCENE= }}
{{STRUCTURE_1qh2| PDB=1qh2 | SCENE= }}
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'''CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA'''
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===CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA===
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==Overview==
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Female reproductive tissues of the ornamental tobacco amass high levels of serine proteinase inhibitors (PIs) for protection against pests and pathogens. These PIs are produced from a precursor protein composed of six repeats each with a protease reactive site. Here we show that proteolytic processing of the precursor generates five single-chain PIs and a remarkable two-chain inhibitor formed by disulfide-bond linkage of N- and C-terminal peptide fragments. Surprisingly, PI precursors adopt this circular structure regardless of the number of inhibitor domains, suggesting this bracelet-like conformation is characteristic of the widespread potato inhibitor II (Pot II) protein family.
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The line below this paragraph, {{ABSTRACT_PUBMED_10360353}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10360353 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10360353}}
==About this Structure==
==About this Structure==
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1QH2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QH2 OCA].
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1QH2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QH2 OCA].
==Reference==
==Reference==
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[[Category: Potato ii trypsin inhibitor]]
[[Category: Potato ii trypsin inhibitor]]
[[Category: Serine proteinase inhibitor]]
[[Category: Serine proteinase inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:15:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:07:02 2008''

Revision as of 05:07, 28 July 2008

Image:1qh2.png

Template:STRUCTURE 1qh2

CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA

Template:ABSTRACT PUBMED 10360353

About this Structure

1QH2 is a Protein complex structure of sequences from Nicotiana alata. Full experimental information is available from OCA.

Reference

A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein., Lee MC, Scanlon MJ, Craik DJ, Anderson MA, Nat Struct Biol. 1999 Jun;6(6):526-30. PMID:10360353

Page seeded by OCA on Mon Jul 28 08:07:02 2008

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