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1qil

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[[Image:1qil.gif|left|200px]]
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{{STRUCTURE_1qil| PDB=1qil | SCENE= }}
{{STRUCTURE_1qil| PDB=1qil | SCENE= }}
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'''INACTIVE MUTANT TOXIC SHOCK SYNDROME TOXIN-1 AT 2.5 A'''
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===INACTIVE MUTANT TOXIC SHOCK SYNDROME TOXIN-1 AT 2.5 A===
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==Overview==
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Toxic shock syndrome toxin-1 (TSST-1) is one of a family of staphylococcal exotoxins recognized as microbial superantigens. The toxin plays a dominant role in the genesis of toxic shock in humans through a massive activation of the immune system. This potentially lethal illness occurs as a result of the interaction of TSST-1 with a significant proportion of the T-cell repertoire. TSST-1, like other superantigens, can bind directly to class II major histocompatibility (MHC class II) molecules prior to its interaction with entire families of V beta chains of the T-cell receptor (TCR). The three-dimensional structure of a mutant (His-135-Ala) TSST-1 was compared with the structure of the native (wild-type) TSST-1 at 2.5 A resolution. The replacement of His 135 of TSST-1 with an Ala residue results in the loss of T-cell mitogenicity and toxicity in experimental animals. This residue, postulated to be directly involved in the toxin-TCR interactions, is located on the major helix alpha 2, which forms the backbone of the molecule and is exposed to the solvent. In the molecular structure of the mutant toxin, the helix alpha 2 remains unaltered, but the His to Ala modification causes perturbations on the neighboring helix alpha 1 by disrupting helix-helix interactions. Thus, the effects on TCR binding of the His 135 residue could actually be mediated, wholly or in part, by the alpha 1 helix.
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(as it appears on PubMed at http://www.pubmed.gov), where 8844860 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8844860}}
==About this Structure==
==About this Structure==
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[[Category: Superantigen]]
[[Category: Superantigen]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:49:44 2008''

Revision as of 10:49, 27 July 2008

Image:1qil.png

Template:STRUCTURE 1qil

INACTIVE MUTANT TOXIC SHOCK SYNDROME TOXIN-1 AT 2.5 A

Template:ABSTRACT PUBMED 8844860

About this Structure

1QIL is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a biologically inactive mutant of toxic shock syndrome toxin-1 at 2.5 A resolution., Papageorgiou AC, Quinn CP, Beer D, Brehm RD, Tranter HS, Bonventre PF, Acharya KR, Protein Sci. 1996 Aug;5(8):1737-41. PMID:8844860

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