1qjs

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{{STRUCTURE_1qjs| PDB=1qjs | SCENE= }}
{{STRUCTURE_1qjs| PDB=1qjs | SCENE= }}
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'''MAMMALIAN BLOOD SERUM HAEMOPEXIN GLYCOSYLATED-NATIVE PROTEIN AND IN COMPLEX WITH ITS LIGAND HAEM'''
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===MAMMALIAN BLOOD SERUM HAEMOPEXIN GLYCOSYLATED-NATIVE PROTEIN AND IN COMPLEX WITH ITS LIGAND HAEM===
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==Overview==
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The ubiquitous use of heme in animals poses severe biological and chemical challenges. Free heme is toxic to cells and is a potential source of iron for pathogens. For protection, especially in conditions of trauma, inflammation and hemolysis, and to maintain iron homeostasis, a high-affinity binding protein, hemopexin, is required. Hemopexin binds heme with the highest affinity of any known protein, but releases it into cells via specific receptors. The crystal structure of the heme-hemopexin complex reveals a novel heme binding site, formed between two similar four-bladed beta-propeller domains and bounded by the interdomain linker. The ligand is bound to two histidine residues in a pocket dominated by aromatic and basic groups. Further stabilization is achieved by the association of the two beta-propeller domains, which form an extensive polar interface that includes a cushion of ordered water molecules. We propose mechanisms by which these structural features provide the dual function of heme binding and release.
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(as it appears on PubMed at http://www.pubmed.gov), where 10504726 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10504726}}
==About this Structure==
==About this Structure==
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[[Category: Haem binding and transport]]
[[Category: Haem binding and transport]]
[[Category: Iron metabolism]]
[[Category: Iron metabolism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:21:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:11:34 2008''

Revision as of 18:11, 28 July 2008

Image:1qjs.png

Template:STRUCTURE 1qjs

MAMMALIAN BLOOD SERUM HAEMOPEXIN GLYCOSYLATED-NATIVE PROTEIN AND IN COMPLEX WITH ITS LIGAND HAEM

Template:ABSTRACT PUBMED 10504726

About this Structure

1QJS is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of hemopexin reveals a novel high-affinity heme site formed between two beta-propeller domains., Paoli M, Anderson BF, Baker HM, Morgan WT, Smith A, Baker EN, Nat Struct Biol. 1999 Oct;6(10):926-31. PMID:10504726

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