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1qk7

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[[Image:1qk7.jpg|left|200px]]
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{{Seed}}
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[[Image:1qk7.png|left|200px]]
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{{STRUCTURE_1qk7| PDB=1qk7 | SCENE= }}
{{STRUCTURE_1qk7| PDB=1qk7 | SCENE= }}
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'''SOLUTION STRUCTURE OF SELENOCOSMIA HUWENA LECTIN-I(SHL-I) BY 2D-NMR'''
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===SOLUTION STRUCTURE OF SELENOCOSMIA HUWENA LECTIN-I(SHL-I) BY 2D-NMR===
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==Overview==
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The three-dimensional structure of native SHL-I, a lectin from the venom of the Chinese bird spider Selenocosmia huwena, has been determined from two-dimensional 1H NMR spectroscopy recorded at 500 and 600 MHz. The best 10 structures have NOE violation &lt;0.3 A, dihedral violation &lt;2 deg, and average root-mean-square differences of 0.85 + 0.06 A over backbone atoms. The structure consists of a three-stranded antiparallel beta-sheet and three turns. The three disulfide bridges and three-stranded antiparallel beta-sheet form a inhibitor cystine knot motif which is adopted by several other small proteins, such as huwentoxin-I, omega-conotoxin, and gurmarin. The C-terminal fragment from Leu28 to Trp32 adopts two sets of conformations corresponding to the cis and trans conformations of Pro31. The structure of SHL-I also has high similarity with that of the N-terminus of hevein, a lectin from rubber-tree latex.
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The line below this paragraph, {{ABSTRACT_PUBMED_10524779}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10524779 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10524779}}
==About this Structure==
==About this Structure==
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1QK7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithoctonus_huwena Ornithoctonus huwena]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK7 OCA].
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1QK7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithoctonus_huwena Ornithoctonus huwena]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK7 OCA].
==Reference==
==Reference==
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[[Category: Selenocosmia huwena]]
[[Category: Selenocosmia huwena]]
[[Category: Shl-i]]
[[Category: Shl-i]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:22:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:40:42 2008''

Revision as of 10:40, 28 July 2008

Image:1qk7.png

Template:STRUCTURE 1qk7

SOLUTION STRUCTURE OF SELENOCOSMIA HUWENA LECTIN-I(SHL-I) BY 2D-NMR

Template:ABSTRACT PUBMED 10524779

About this Structure

1QK7 is a Single protein structure of sequence from Ornithoctonus huwena. Full experimental information is available from OCA.

Reference

Three-dimensional structure of Selenocosmia huwena lectin-I (SHL-I) from the venom of the spider Selenocosmia huwena by 2D-NMR., Lu S, Liang S, Gu X, J Protein Chem. 1999 Jul;18(5):609-17. PMID:10524779

Page seeded by OCA on Mon Jul 28 13:40:42 2008

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