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1qlg

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[[Image:1qlg.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1qlg| PDB=1qlg | SCENE= }}
{{STRUCTURE_1qlg| PDB=1qlg | SCENE= }}
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'''CRYSTAL STRUCTURE OF PHYTASE WITH MAGNESIUM FROM BACILLUS AMYLOLIQUEFACIENS'''
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===CRYSTAL STRUCTURE OF PHYTASE WITH MAGNESIUM FROM BACILLUS AMYLOLIQUEFACIENS===
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==Overview==
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Phytases hydrolyze phytic acid to less phosphorylated myo-inositol derivatives and inorganic phosphate. A thermostable phytase is of great value in applications for improving phosphate and metal ion availability in animal feed, and thereby reducing phosphate pollution to the environment. Here, we report a new folding architecture of a six-bladed propeller for phosphatase activity revealed by the 2.1 A crystal structures of a novel, thermostable phytase determined in both the partially and fully Ca2+-loaded states. Binding of two calcium ions to high-affinity calcium binding sites results in a dramatic increase in thermostability (by as much as approximately 30 degrees C in melting temperature) by joining loop segments remote in the amino acid sequence. Binding of three additional calcium ions to low-affinity calcium binding sites at the top of the molecule turns on the catalytic activity of the enzyme by converting the highly negatively charged cleft into a favorable environment for the binding of phytate.
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The line below this paragraph, {{ABSTRACT_PUBMED_10655618}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10655618 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10655618}}
==About this Structure==
==About this Structure==
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[[Category: Phytase]]
[[Category: Phytase]]
[[Category: Thermostable]]
[[Category: Thermostable]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:24:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:52:36 2008''

Revision as of 00:52, 29 July 2008

Image:1qlg.png

Template:STRUCTURE 1qlg

CRYSTAL STRUCTURE OF PHYTASE WITH MAGNESIUM FROM BACILLUS AMYLOLIQUEFACIENS

Template:ABSTRACT PUBMED 10655618

About this Structure

1QLG is a Single protein structure of sequence from Bacillus amyloliquefaciens. Full crystallographic information is available from OCA.

Reference

Crystal structures of a novel, thermostable phytase in partially and fully calcium-loaded states., Ha NC, Oh BC, Shin S, Kim HJ, Oh TK, Kim YO, Choi KY, Oh BH, Nat Struct Biol. 2000 Feb;7(2):147-53. PMID:10655618

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