1qm0

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{{STRUCTURE_1qm0| PDB=1qm0 | SCENE= }}
{{STRUCTURE_1qm0| PDB=1qm0 | SCENE= }}
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'''HUMAN PRION PROTEIN FRAGMENT 90-230'''
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===HUMAN PRION PROTEIN FRAGMENT 90-230===
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==Overview==
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The NMR structures of the recombinant human prion protein, hPrP(23-230), and two C-terminal fragments, hPrP(90-230) and hPrP(121-230), include a globular domain extending from residues 125-228, for which a detailed structure was obtained, and an N-terminal flexibly disordered "tail." The globular domain contains three alpha-helices comprising the residues 144-154, 173-194, and 200-228 and a short anti-parallel beta-sheet comprising the residues 128-131 and 161-164. Within the globular domain, three polypeptide segments show increased structural disorder: i.e., a loop of residues 167-171, the residues 187-194 at the end of helix 2, and the residues 219-228 in the C-terminal part of helix 3. The local conformational state of the polypeptide segments 187-193 in helix 2 and 219-226 in helix 3 is measurably influenced by the length of the N-terminal tail, with the helical states being most highly populated in hPrP(23-230). When compared with the previously reported structures of the murine and Syrian hamster prion proteins, the length of helix 3 coincides more closely with that in the Syrian hamster protein whereas the disordered loop 167-171 is shared with murine PrP. These species variations of local structure are in a surface area of the cellular form of PrP that has previously been implicated in intermolecular interactions related both to the species barrier for infectious transmission of prion disease and to immune reactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 10618385 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10618385}}
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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1QM0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QM0 OCA].
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1QM0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QM0 OCA].
==Reference==
==Reference==
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[[Category: Prion]]
[[Category: Prion]]
[[Category: Repeat]]
[[Category: Repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:26:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:18:25 2008''

Revision as of 06:18, 28 July 2008

Image:1qm0.png

Template:STRUCTURE 1qm0

Contents

HUMAN PRION PROTEIN FRAGMENT 90-230

Template:ABSTRACT PUBMED 10618385

Disease

Known disease associated with this structure: Creutzfeldt-Jakob disease OMIM:[176640], Gerstmann-Straussler disease OMIM:[176640], Huntington disease-like 1 OMIM:[176640], Insomnia, fatal familial OMIM:[176640], Prion disease with protracted course OMIM:[176640]

About this Structure

1QM0 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

NMR solution structure of the human prion protein., Zahn R, Liu A, Luhrs T, Riek R, von Schroetter C, Lopez Garcia F, Billeter M, Calzolai L, Wider G, Wuthrich K, Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):145-50. PMID:10618385

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