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1qmz

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[[Image:1qmz.jpg|left|200px]]
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{{Seed}}
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[[Image:1qmz.png|left|200px]]
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{{STRUCTURE_1qmz| PDB=1qmz | SCENE= }}
{{STRUCTURE_1qmz| PDB=1qmz | SCENE= }}
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'''PHOSPHORYLATED CDK2-CYCLYIN A-SUBSTRATE PEPTIDE COMPLEX'''
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===PHOSPHORYLATED CDK2-CYCLYIN A-SUBSTRATE PEPTIDE COMPLEX===
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==Overview==
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Progression through the eukaryotic cell cycle is driven by the orderly activation of cyclin-dependent kinases (CDKs). For activity, CDKs require association with a cyclin and phosphorylation by a separate protein kinase at a conserved threonine residue (T160 in CDK2). Here we present the structure of a complex consisting of phosphorylated CDK2 and cyclin A together with an optimal peptide substrate, HHASPRK. This structure provides an explanation for the specificity of CDK2 towards the proline that follows the phosphorylatable serine of the substrate peptide, and the requirement for the basic residue in the P+3 position of the substrate. We also present the structure of phosphorylated CDK2 plus cyclin A3 in complex with residues 658-668 from the CDK2 substrate p107. These residues include the RXL motif required to target p107 to cyclins. This structure explains the specificity of the RXL motif for cyclins.
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The line below this paragraph, {{ABSTRACT_PUBMED_10559988}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10559988 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10559988}}
==About this Structure==
==About this Structure==
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Substrate complex]]
[[Category: Substrate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:28:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:42:25 2008''

Revision as of 09:42, 29 July 2008

Image:1qmz.png

Template:STRUCTURE 1qmz

PHOSPHORYLATED CDK2-CYCLYIN A-SUBSTRATE PEPTIDE COMPLEX

Template:ABSTRACT PUBMED 10559988

About this Structure

1QMZ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases., Brown NR, Noble ME, Endicott JA, Johnson LN, Nat Cell Biol. 1999 Nov;1(7):438-43. PMID:10559988

Page seeded by OCA on Tue Jul 29 12:42:25 2008

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