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1sra
From Proteopedia
(New page: 200px<br /> <applet load="1sra" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sra, resolution 2.0Å" /> '''STRUCTURE OF A NOVEL...) |
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| - | [[Image:1sra. | + | [[Image:1sra.jpg|left|200px]]<br /><applet load="1sra" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1sra, resolution 2.0Å" /> | caption="1sra, resolution 2.0Å" /> | ||
'''STRUCTURE OF A NOVEL EXTRACELLULAR CA2+-BINDING MODULE IN BM-40(SLASH)SPARC(SLASH)OSTEONECTIN'''<br /> | '''STRUCTURE OF A NOVEL EXTRACELLULAR CA2+-BINDING MODULE IN BM-40(SLASH)SPARC(SLASH)OSTEONECTIN'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1SRA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1SRA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SRA OCA]. |
==Reference== | ==Reference== | ||
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[[Category: extracellular matrix protein]] | [[Category: extracellular matrix protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:54:36 2008'' |
Revision as of 14:54, 15 February 2008
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STRUCTURE OF A NOVEL EXTRACELLULAR CA2+-BINDING MODULE IN BM-40(SLASH)SPARC(SLASH)OSTEONECTIN
Overview
The EF-hand is a highly conserved Ca(2+)-binding motif found in many, cytosolic Ca(2+)-modulated proteins. Here we report the crystal structure, at 2.0 A resolution of the carboxy-terminal domain of human BM-40 (SPARC, osteonectin), an extracellular matrix protein containing an EF-hand pair., The two EF-hands interact canonically but their detailed structures are, unusual. In the first EF-hand a one-residue insertion is accommodated by a, cis-peptide bond and by substituting a carboxylate by a peptide carbonyl, as a Ca2+ ligand. The second EF-hand is stabilized by a disulphide bond., The EF-hand pair interacts tightly with an amphiphilic amino-terminal, helix, reminiscent of target peptide binding by calmodulin. The present, structure defines a novel protein module occurring in several other, extracellular proteins.
About this Structure
1SRA is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Structure of a novel extracellular Ca(2+)-binding module in BM-40., Hohenester E, Maurer P, Hohenadl C, Timpl R, Jansonius JN, Engel J, Nat Struct Biol. 1996 Jan;3(1):67-73. PMID:8548457
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