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1qnt

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[[Image:1qnt.gif|left|200px]]
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{{STRUCTURE_1qnt| PDB=1qnt | SCENE= }}
{{STRUCTURE_1qnt| PDB=1qnt | SCENE= }}
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'''X-RAY STRUCTURE OF HUMAN O6ALKYLGUANINE-DNA ALKYLTRANSFERASE'''
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===X-RAY STRUCTURE OF HUMAN O6ALKYLGUANINE-DNA ALKYLTRANSFERASE===
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==Overview==
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The mutagenic and carcinogenic effects of simple alkylating agents are mainly due to O(6)-alkylation of guanine in DNA. This lesion results in transition mutations. In both prokaryotic and eukaryotic cells, repair is effected by direct reversal of the damage by a suicide protein, O(6)-alkylguanine-DNA alkyltransferase. The alkyltransferase removes the alkyl group to one of its own cysteine residues. However, this mechanism for preserving genomic integrity limits the effectiveness of certain alkylating anticancer agents. A high level of the alkyltransferase in many tumour cells renders them resistant to such drugs. Here we report the X-ray structure of the human alkyltransferase solved using the technique of multiple wavelength anomalous dispersion. This structure explains the markedly different specificities towards various O(6)-alkyl lesions and inhibitors when compared with the Escherichia coli protein (for which the structure has already been determined). It is also used to interpret the behaviour of certain mutant alkyltransferases to enhance biochemical understanding of the protein. Further examination of the various models proposed for DNA binding is also permitted. This structure may be useful for the design and refinement of drugs as chemoenhancers of alkylating agent chemotherapy.
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The line below this paragraph, {{ABSTRACT_PUBMED_10606635}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10606635 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10606635}}
==About this Structure==
==About this Structure==
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[[Category: Dna repair]]
[[Category: Dna repair]]
[[Category: Methyltransferase]]
[[Category: Methyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:29:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:50:47 2008''

Revision as of 01:50, 29 July 2008

Image:1qnt.png

Template:STRUCTURE 1qnt

X-RAY STRUCTURE OF HUMAN O6ALKYLGUANINE-DNA ALKYLTRANSFERASE

Template:ABSTRACT PUBMED 10606635

About this Structure

1QNT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase., Wibley JE, Pegg AE, Moody PC, Nucleic Acids Res. 2000 Jan 15;28(2):393-401. PMID:10606635

Page seeded by OCA on Tue Jul 29 04:50:47 2008

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