1qo0

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{{STRUCTURE_1qo0| PDB=1qo0 | SCENE= }}
{{STRUCTURE_1qo0| PDB=1qo0 | SCENE= }}
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'''AMIDE RECEPTOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH THE NEGATIVE REGULATOR AMIR.'''
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===AMIDE RECEPTOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH THE NEGATIVE REGULATOR AMIR.===
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==Overview==
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Inducible expression of the aliphatic amidase operon in Pseudomonas aeruginosa is controlled by an antitermination mechanism which allows production of the full-length transcript only in the presence of small-molecule inducers, such as acetamide. Ligand-regulated antitermination is provided by AmiC, the ligand-sensitive negative regulator, and AmiR, the RNA-binding positive regulator. Under non-inducing or repressing growth conditions, AmiC and AmiR form a complex in which the activity of AmiR is silenced. The crystal structure of the AmiC-AmiR complex identifies AmiR as a new and highly unusual member of the response-regulator family of bacterial signal transduction proteins, regulated by sequestration rather than phosphorylation. Comparison with the structure of free AmiC reveals the subtle mechanism of ligand-induced release of AmiR.
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{{ABSTRACT_PUBMED_10508151}}
==About this Structure==
==About this Structure==
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[[Category: Gene regulator]]
[[Category: Gene regulator]]
[[Category: Receptor]]
[[Category: Receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:30:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:47:14 2008''

Revision as of 10:47, 27 July 2008

Image:1qo0.png

Template:STRUCTURE 1qo0

AMIDE RECEPTOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH THE NEGATIVE REGULATOR AMIR.

Template:ABSTRACT PUBMED 10508151

About this Structure

1QO0 is a Protein complex structure of sequences from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Crystal structure and induction mechanism of AmiC-AmiR: a ligand-regulated transcription antitermination complex., O'Hara BP, Norman RA, Wan PT, Roe SM, Barrett TE, Drew RE, Pearl LH, EMBO J. 1999 Oct 1;18(19):5175-86. PMID:10508151

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